Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting

Alun Williams; Adam Gow; Scott Kilpatrick; Mickey Tivers; Vicky Lipscomb; Ken Smith; Michael Oliver Day; Nick Jeffery; Richard John Mellanby

doi:10.4142/jvs.2020.21.e44

Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting

Alun Williams, Adam Gow, Scott Kilpatrick, Mickey Tivers, Vicky Lipscomb, Ken Smith, Michael Oliver Day, Nick Jeffery, Richard John Mellanby

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Congenital portosystemic shunt (cPSS) is one of the most common congenital disorders diagnosed in dogs. Hepatic encephalopathy (HE) is a frequent complication in dogs with a cPSS and is a major cause of morbidity and mortality. Despite HE been a major cause of morbidity in dogs with a cPSS, little is known about the cellular changes that occur in the central nervous system of dogs with a cPSS.

OBJECTIVES: The objective of this study was to characterise the histological changes in the cerebral cortex and cerebellum of dogs with cPSS with particular emphasis on astrocyte morphology.

METHODS: Eight dogs with a confirmed cPSS were included in the study.

RESULTS: Six dogs had substantial numbers of Alzheimer type II astrocytes and all cases had increased immunoreactivity for glial fibrillary acidic protein in the cerebral cortex, even if there were minimal other morphological changes.

CONCLUSIONS: This study demonstrates that dogs with a cPSS have marked cellular changes in the cerebral cortex and cerebellum. The cellular changes that occur in the cerebral cortex and cerebellum of dogs with spontaneously arising HE are similar to changes which occur in humans with HE, further validating dogs with a cPSS as a good model for human HE.

Original language	English
Pages (from-to)	e44
Journal	Journal of Veterinary Science
Volume	21
Issue number	3
DOIs	https://doi.org/10.4142/jvs.2020.21.e44
Publication status	Published - 23 Apr 2020

Keywords / Materials (for Non-textual outputs)

Astrocytes
hepatic encephalopathy
dogs
portosystemic

Access to Document

10.4142/jvs.2020.21.e44

jvs-21-e44
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:// creative commons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited
Final published version, 3.48 MBLicence: Creative Commons: Attribution (CC-BY)

Cite this

@article{494eea2323e9465a9bd94dbb55b4a5fe,

title = "Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting",

abstract = "BACKGROUND: Congenital portosystemic shunt (cPSS) is one of the most common congenital disorders diagnosed in dogs. Hepatic encephalopathy (HE) is a frequent complication in dogs with a cPSS and is a major cause of morbidity and mortality. Despite HE been a major cause of morbidity in dogs with a cPSS, little is known about the cellular changes that occur in the central nervous system of dogs with a cPSS.OBJECTIVES: The objective of this study was to characterise the histological changes in the cerebral cortex and cerebellum of dogs with cPSS with particular emphasis on astrocyte morphology.METHODS: Eight dogs with a confirmed cPSS were included in the study.RESULTS: Six dogs had substantial numbers of Alzheimer type II astrocytes and all cases had increased immunoreactivity for glial fibrillary acidic protein in the cerebral cortex, even if there were minimal other morphological changes.CONCLUSIONS: This study demonstrates that dogs with a cPSS have marked cellular changes in the cerebral cortex and cerebellum. The cellular changes that occur in the cerebral cortex and cerebellum of dogs with spontaneously arising HE are similar to changes which occur in humans with HE, further validating dogs with a cPSS as a good model for human HE.",

keywords = "Astrocytes, hepatic encephalopathy, dogs, portosystemic",

author = "Alun Williams and Adam Gow and Scott Kilpatrick and Mickey Tivers and Vicky Lipscomb and Ken Smith and Day, {Michael Oliver} and Nick Jeffery and Mellanby, {Richard John}",

note = "{\textcopyright} 2020 The Korean Society of Veterinary Science.",

year = "2020",

month = apr,

day = "23",

doi = "10.4142/jvs.2020.21.e44",

language = "English",

volume = "21",

pages = "e44",

journal = "Journal of Veterinary Science",

issn = "1976-555X",

publisher = "Korean Society of Veterinary Science",

number = "3",

}

TY - JOUR

T1 - Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting

AU - Williams, Alun

AU - Gow, Adam

AU - Kilpatrick, Scott

AU - Tivers, Mickey

AU - Lipscomb, Vicky

AU - Smith, Ken

AU - Day, Michael Oliver

AU - Jeffery, Nick

AU - Mellanby, Richard John

PY - 2020/4/23

Y1 - 2020/4/23

N2 - BACKGROUND: Congenital portosystemic shunt (cPSS) is one of the most common congenital disorders diagnosed in dogs. Hepatic encephalopathy (HE) is a frequent complication in dogs with a cPSS and is a major cause of morbidity and mortality. Despite HE been a major cause of morbidity in dogs with a cPSS, little is known about the cellular changes that occur in the central nervous system of dogs with a cPSS.OBJECTIVES: The objective of this study was to characterise the histological changes in the cerebral cortex and cerebellum of dogs with cPSS with particular emphasis on astrocyte morphology.METHODS: Eight dogs with a confirmed cPSS were included in the study.RESULTS: Six dogs had substantial numbers of Alzheimer type II astrocytes and all cases had increased immunoreactivity for glial fibrillary acidic protein in the cerebral cortex, even if there were minimal other morphological changes.CONCLUSIONS: This study demonstrates that dogs with a cPSS have marked cellular changes in the cerebral cortex and cerebellum. The cellular changes that occur in the cerebral cortex and cerebellum of dogs with spontaneously arising HE are similar to changes which occur in humans with HE, further validating dogs with a cPSS as a good model for human HE.

AB - BACKGROUND: Congenital portosystemic shunt (cPSS) is one of the most common congenital disorders diagnosed in dogs. Hepatic encephalopathy (HE) is a frequent complication in dogs with a cPSS and is a major cause of morbidity and mortality. Despite HE been a major cause of morbidity in dogs with a cPSS, little is known about the cellular changes that occur in the central nervous system of dogs with a cPSS.OBJECTIVES: The objective of this study was to characterise the histological changes in the cerebral cortex and cerebellum of dogs with cPSS with particular emphasis on astrocyte morphology.METHODS: Eight dogs with a confirmed cPSS were included in the study.RESULTS: Six dogs had substantial numbers of Alzheimer type II astrocytes and all cases had increased immunoreactivity for glial fibrillary acidic protein in the cerebral cortex, even if there were minimal other morphological changes.CONCLUSIONS: This study demonstrates that dogs with a cPSS have marked cellular changes in the cerebral cortex and cerebellum. The cellular changes that occur in the cerebral cortex and cerebellum of dogs with spontaneously arising HE are similar to changes which occur in humans with HE, further validating dogs with a cPSS as a good model for human HE.

KW - Astrocytes

KW - hepatic encephalopathy

KW - dogs

KW - portosystemic

U2 - 10.4142/jvs.2020.21.e44

DO - 10.4142/jvs.2020.21.e44

M3 - Article

C2 - 32476318

SN - 1976-555X

VL - 21

SP - e44

JO - Journal of Veterinary Science

JF - Journal of Veterinary Science

IS - 3

ER -

Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Cite this