Asymptomatic Rotavirus Infections in England: Prevalence, Characteristics, and Risk Factors

Gemma Phillips*, Ben Lopman, Laura C. Rodrigues, Clarence C. Tam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Rotavirus is a major cause of infectious intestinal disease in young children; a substantial prevalence of asymptomatic infection has been reported across all age groups. In this study, the authors determined characteristics of asymptomatic rotavirus infection and potential risk factors for infection. Healthy persons were recruited at random from the general population of England during the Study of Infectious Intestinal Disease in England (1993-1996). Rotavirus infection was identified using reverse-transcription polymerase chain reaction. Multivariable logistic regression was used to compare exposures reported by participants with rotavirus infection with those of participants who tested negative. Multiple imputation was used to account for missing responses in the data set. The age-adjusted prevalence of asymptomatic rotavirus infection was 11%; prevalence was highest in children under age 18 years. Attendance at day care was a risk factor for asymptomatic rotavirus infection in children under age 5 years; living in a household with a baby that was still in diapers was a risk factor in older adults. The results suggest that asymptomatic rotavirus infection is transmitted through the same route as rotavirus infectious intestinal disease: person-to-person contact. More work is needed to understand the role of asymptomatic infections in transmission leading to rotavirus disease.

Original languageEnglish
Pages (from-to)1023-1030
Number of pages8
JournalAmerican Journal of Epidemiology
Volume171
Issue number9
DOIs
Publication statusPublished - 1 May 2010

Keywords

  • case-control studies
  • logistic models
  • polymerase chain reaction
  • risk factors
  • rotavirus infections
  • DAY-CARE-CENTERS
  • GROUP-A ROTAVIRUS
  • INTESTINAL DISEASE
  • CHILDHOOD DIARRHEA
  • PROTECTIVE FACTORS
  • ENTERIC VIRUSES
  • YOUNG-CHILDREN
  • SOUTH-INDIA
  • SAO-PAULO
  • ADULTS

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