Attached Ultrasound Contrast Agents

M. B. Butler, C. Moran, S. D. Pye, J. Ross, V. Sboros, W. N. McDicken

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent data indicate that plasticity protocols have not only synapse-specific but also more widespread effects. In particular, in synaptic tagging and capture (STC), tagged synapses can capture plasticity-related proteins, synthesized in response to strong stimulation of other synapses. This leads to long-lasting modification of only weakly stimulated synapses. Here we present a biophysical model of synaptic plasticity in the hippocampus that incorporates several key results from experiments on STC. The model specifies a set of physical states in which a synapse can exist, together with transition rates that are affected by high- and low-frequency stimulation protocols. In contrast to most standard plasticity models, the model exhibits both early- and late-phase LTP/D, de-potentiation, and STC. As such, it provides a useful starting point for further theoretical work on the role of STC in learning and memory.
Original languageEnglish
Title of host publicationInstitute of Acoustics
Pages397-404
Number of pages8
Publication statusPublished - 2008

Keywords

  • Animals
  • Electric Stimulation
  • Evoked Potentials
  • Hippocampus/physiology
  • Humans
  • Long-Term Potentiation/*physiology
  • Memory/physiology
  • *Models, Neurological
  • Nerve Net/physiology
  • Nerve Tissue Proteins/metabolism
  • Neurons/metabolism
  • Stochastic Processes
  • Synapses/genetics/metabolism
  • Synaptic Transmission/*physiology

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