Attaching palladium catalysts to antibodies

Paul Cowling, Mark Bradley, Annamaria Lilienkampf

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Antibody-directed enzyme prodrug therapy (ADEPT) is a powerful concept in which antibody targeting is linked to enzymatic prodrug activation. The work herein describes the first steps in the development of a technology analogous to ADEPT but in which a palladium catalyst is attached of an antibody rather than an enzyme. Antibody–metal conjugates have been used in a variety of contexts including for radiotherapy; however, none of the metals attached to the antibodies have been used for catalytic purposes. This work represents the first example a metal being attached to an antibody for the purposes of carrying a functional catalyst.
Original languageEnglish
Article number116298
JournalBioorganic and Medicinal Chemistry
Early online date28 Jun 2021
Publication statusE-pub ahead of print - 28 Jun 2021


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