Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations

A. M. Brooks; N. Walker; A. Aldibbiat; S. Hughes; G. Jones; J. de Havilland; P. Choudhary; G. C. Huang; N. Parrott; N. W. A. McGowan; J. Casey; L. Mumford; P. Barker; K. Burling; R. Hovorka; M. Walker; R. M. Smith; S. Forbes; M. K. Rutter; S. Amiel; M. J. Rosenthal; P. Johnson; J. A. M. Shaw

doi:10.1111/ajt.12469

Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations

A. M. Brooks, N. Walker, A. Aldibbiat, S. Hughes, G. Jones, J. de Havilland, P. Choudhary, G. C. Huang, N. Parrott, N. W. A. McGowan, J. Casey, L. Mumford, P. Barker, K. Burling, R. Hovorka, M. Walker, R. M. Smith, S. Forbes, M. K. Rutter, S. AmielM. J. Rosenthal, P. Johnson, J. A. M. Shaw^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The objective was to determine whether metabolic goals have been achieved with locally isolated and transported preparations over the first 3 years of the UK's nationally funded integrated islet transplant program. Twenty islet recipients with C-peptide negative type 1 diabetes and recurrent severe hypoglycemia consented to the study, including standardized meal tolerance tests. Participants received a total of 35 infusions (seven recipients: single graft; 11 recipients: two grafts: two recipients: three grafts). Graft function was maintained in 80% at [median (interquartile range)] 24 (13.5-36) months postfirst transplant. Severe hypoglycemia was reduced from 20 (7-50) episodes/patient-year pretransplant to 0.3 (0-1.6) episodes/patient-year posttransplant (p

In this report on a cohort of recipients within the UK government-funded fully integrated islet transplant program, the authors demonstrate attainment of metabolic goals with both locally isolated and transported islets with comparable graft survival up to 36 months posttransplant.

Original language	English
Pages (from-to)	3236-3243
Number of pages	8
Journal	American Journal of Transplantation
Volume	13
Issue number	12
DOIs	https://doi.org/10.1111/ajt.12469
Publication status	Published - Dec 2013

Keywords

Islet transplantation
islet transport
meal tolerance test
severe hypoglycemia
TYPE-1 DIABETES-MELLITUS
SINGLE-DONOR
FOLLOW-UP
HYPOGLYCEMIA
FREQUENCY
AWARENESS
TIME

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Islet transplantation from a nationally funded UK centre reaches socially deprived groups and improves metabolic outcomes
Forbes, S., McGowan, N. W. A., Duncan, K., Anderson, D., Barclay, J., Mitchell, D., Docherty, K., Turner, D., Campbell, J. D. M. & Casey, J., Jun 2015, In: Diabetologia. 58, 6, p. 1300-1308
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Brooks, A. M., Walker, N., Aldibbiat, A., Hughes, S., Jones, G., de Havilland, J., Choudhary, P., Huang, G. C., Parrott, N., McGowan, N. W. A., Casey, J., Mumford, L., Barker, P., Burling, K., Hovorka, R., Walker, M., Smith, R. M., Forbes, S., Rutter, M. K., ... Shaw, J. A. M. (2013). Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations. American Journal of Transplantation, 13(12), 3236-3243. https://doi.org/10.1111/ajt.12469

@article{61b5fe66d76047b2895d21b79d81abe1,

title = "Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations",

abstract = "The objective was to determine whether metabolic goals have been achieved with locally isolated and transported preparations over the first 3 years of the UK's nationally funded integrated islet transplant program. Twenty islet recipients with C-peptide negative type 1 diabetes and recurrent severe hypoglycemia consented to the study, including standardized meal tolerance tests. Participants received a total of 35 infusions (seven recipients: single graft; 11 recipients: two grafts: two recipients: three grafts). Graft function was maintained in 80% at [median (interquartile range)] 24 (13.5-36) months postfirst transplant. Severe hypoglycemia was reduced from 20 (7-50) episodes/patient-year pretransplant to 0.3 (0-1.6) episodes/patient-year posttransplant (pIn this report on a cohort of recipients within the UK government-funded fully integrated islet transplant program, the authors demonstrate attainment of metabolic goals with both locally isolated and transported islets with comparable graft survival up to 36 months posttransplant.",

keywords = "Islet transplantation, islet transport, meal tolerance test, severe hypoglycemia, TYPE-1 DIABETES-MELLITUS, SINGLE-DONOR, FOLLOW-UP, HYPOGLYCEMIA, FREQUENCY, AWARENESS, TIME",

author = "Brooks, {A. M.} and N. Walker and A. Aldibbiat and S. Hughes and G. Jones and {de Havilland}, J. and P. Choudhary and Huang, {G. C.} and N. Parrott and McGowan, {N. W. A.} and J. Casey and L. Mumford and P. Barker and K. Burling and R. Hovorka and M. Walker and Smith, {R. M.} and S. Forbes and Rutter, {M. K.} and S. Amiel and Rosenthal, {M. J.} and P. Johnson and Shaw, {J. A. M.}",

year = "2013",

month = dec,

doi = "10.1111/ajt.12469",

language = "English",

volume = "13",

pages = "3236--3243",

journal = "American Journal of Transplantation",

issn = "1600-6135",

publisher = "Wiley-Blackwell",

number = "12",

}

Brooks, AM, Walker, N, Aldibbiat, A, Hughes, S, Jones, G, de Havilland, J, Choudhary, P, Huang, GC, Parrott, N, McGowan, NWA, Casey, J, Mumford, L, Barker, P, Burling, K, Hovorka, R, Walker, M, Smith, RM, Forbes, S, Rutter, MK, Amiel, S, Rosenthal, MJ, Johnson, P & Shaw, JAM 2013, 'Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations', American Journal of Transplantation, vol. 13, no. 12, pp. 3236-3243. https://doi.org/10.1111/ajt.12469

TY - JOUR

T1 - Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations

AU - Brooks, A. M.

AU - Walker, N.

AU - Aldibbiat, A.

AU - Hughes, S.

AU - Jones, G.

AU - de Havilland, J.

AU - Choudhary, P.

AU - Huang, G. C.

AU - Parrott, N.

AU - McGowan, N. W. A.

AU - Casey, J.

AU - Mumford, L.

AU - Barker, P.

AU - Burling, K.

AU - Hovorka, R.

AU - Walker, M.

AU - Smith, R. M.

AU - Forbes, S.

AU - Rutter, M. K.

AU - Amiel, S.

AU - Rosenthal, M. J.

AU - Johnson, P.

AU - Shaw, J. A. M.

PY - 2013/12

Y1 - 2013/12

N2 - The objective was to determine whether metabolic goals have been achieved with locally isolated and transported preparations over the first 3 years of the UK's nationally funded integrated islet transplant program. Twenty islet recipients with C-peptide negative type 1 diabetes and recurrent severe hypoglycemia consented to the study, including standardized meal tolerance tests. Participants received a total of 35 infusions (seven recipients: single graft; 11 recipients: two grafts: two recipients: three grafts). Graft function was maintained in 80% at [median (interquartile range)] 24 (13.5-36) months postfirst transplant. Severe hypoglycemia was reduced from 20 (7-50) episodes/patient-year pretransplant to 0.3 (0-1.6) episodes/patient-year posttransplant (pIn this report on a cohort of recipients within the UK government-funded fully integrated islet transplant program, the authors demonstrate attainment of metabolic goals with both locally isolated and transported islets with comparable graft survival up to 36 months posttransplant.

AB - The objective was to determine whether metabolic goals have been achieved with locally isolated and transported preparations over the first 3 years of the UK's nationally funded integrated islet transplant program. Twenty islet recipients with C-peptide negative type 1 diabetes and recurrent severe hypoglycemia consented to the study, including standardized meal tolerance tests. Participants received a total of 35 infusions (seven recipients: single graft; 11 recipients: two grafts: two recipients: three grafts). Graft function was maintained in 80% at [median (interquartile range)] 24 (13.5-36) months postfirst transplant. Severe hypoglycemia was reduced from 20 (7-50) episodes/patient-year pretransplant to 0.3 (0-1.6) episodes/patient-year posttransplant (pIn this report on a cohort of recipients within the UK government-funded fully integrated islet transplant program, the authors demonstrate attainment of metabolic goals with both locally isolated and transported islets with comparable graft survival up to 36 months posttransplant.

KW - Islet transplantation

KW - islet transport

KW - meal tolerance test

KW - severe hypoglycemia

KW - TYPE-1 DIABETES-MELLITUS

KW - SINGLE-DONOR

KW - FOLLOW-UP

KW - HYPOGLYCEMIA

KW - FREQUENCY

KW - AWARENESS

KW - TIME

U2 - 10.1111/ajt.12469

DO - 10.1111/ajt.12469

M3 - Article

VL - 13

SP - 3236

EP - 3243

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 12

ER -

Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations

Abstract

Keywords

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Research output

Islet transplantation from a nationally funded UK centre reaches socially deprived groups and improves metabolic outcomes

Cite this