Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations

A. M. Brooks, N. Walker, A. Aldibbiat, S. Hughes, G. Jones, J. de Havilland, P. Choudhary, G. C. Huang, N. Parrott, N. W. A. McGowan, J. Casey, L. Mumford, P. Barker, K. Burling, R. Hovorka, M. Walker, R. M. Smith, S. Forbes, M. K. Rutter, S. AmielM. J. Rosenthal, P. Johnson, J. A. M. Shaw*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The objective was to determine whether metabolic goals have been achieved with locally isolated and transported preparations over the first 3 years of the UK's nationally funded integrated islet transplant program. Twenty islet recipients with C-peptide negative type 1 diabetes and recurrent severe hypoglycemia consented to the study, including standardized meal tolerance tests. Participants received a total of 35 infusions (seven recipients: single graft; 11 recipients: two grafts: two recipients: three grafts). Graft function was maintained in 80% at [median (interquartile range)] 24 (13.5-36) months postfirst transplant. Severe hypoglycemia was reduced from 20 (7-50) episodes/patient-year pretransplant to 0.3 (0-1.6) episodes/patient-year posttransplant (p

In this report on a cohort of recipients within the UK government-funded fully integrated islet transplant program, the authors demonstrate attainment of metabolic goals with both locally isolated and transported islets with comparable graft survival up to 36 months posttransplant.

Original languageEnglish
Pages (from-to)3236-3243
Number of pages8
JournalAmerican Journal of Transplantation
Issue number12
Publication statusPublished - Dec 2013


  • Islet transplantation
  • islet transport
  • meal tolerance test
  • severe hypoglycemia
  • TIME


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