Projects per year
Abstract
Fallopian tube (FT) and endometrial urocortin 1 (Ucn1) and corticotropin-releasing hormone (CRH)-receptor (CRH-R1/CRH-R2) expression were examined using quantitative real-time polymerase chain reaction (RT-PCR) and immunohistochemistry in nonpregnant and pregnant women (intrauterine, IUP; ectopic pregnancy, EP). Tubal Ucn1 messenger RNA (mRNA) expression was higher in luteal compared to follicular phase (P <.01) and equivalent to follicular phase in FT from EP. Tubal CRH-R1/CRH-R2 mRNA was lower in luteal phase (P <.05) and in FT from EP compared to follicular phase (P <.01). Ucn1 mRNA was lower in endometrium from EP compared to IUP (P <.05). Corticotropin-releasing hormone-R1 mRNA was higher in endometrium from EP compared to viable IUP (P <.05). No differences were observed in CRH-R2 expression. Corticotropin-releasing hormone-R1 protein was primarily localized to epithelium of FT and endometrium. Quantitative analysis of tubal CRH-R1 protein expression reflected that seen at the mRNA level but endometrial expression was equivocal. The demonstration of attenuated tubal/endometrial Ucn1/CRH-R expression in EP further supports a role of the CRH-family in embryo implantation.
Original language | English |
---|---|
Pages (from-to) | 261-8 |
Number of pages | 8 |
Journal | Reproductive Sciences |
Volume | 18 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2011 |
Keywords / Materials (for Non-textual outputs)
- Urocortin 1
- corticotrophin releasing hormone receptor
- Fallopian tube
- Endometrium
- Ectopic pregnancy
Fingerprint
Dive into the research topics of 'Attenuated tubal and endometrial urocortin 1 and corticotropin-releasing hormone receptor expression in ectopic pregnancy'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Aberrant prokineticin expression as a ..
Horne, A. (Principal Investigator) & Critchley, H. (Co-investigator)
1/05/08 → 30/04/11
Project: Research