Atypical neurofibromatosis type 1 with unilateral limb hypertrophy mimicking overgrowth syndrome

K. Tripolszki, K. Farkas, A. Sulák, G. Szolnoky, B. Duga, B. Melegh, R. G. Knox, V. E.R. Parker, R. K. Semple, L. Kemény, M. Széll, N. Nagy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Neurofibromatosis type 1 (NF1; OMIM 162200), a dominantly inherited multitumor syndrome, results from mutations in the Neurofibromin 1 (NF1) gene. We present the case of a Hungarian woman with the clinical phenotype of NF1 over her whole body and the clinical features of unilateral overgrowth involving her entire left leg. This unusual phenotype suggested either the atypical form of NF1 or the coexistence of NF1 and overgrowth syndrome. Direct sequencing of the genomic DNA isolated from peripheral blood revealed a novel frameshift mutation (c.5727insT, p.V1909fsX1912) in the NF1 gene. Next-generation sequencing of 50 oncogenes and tumour suppressor genes, performed on the genomic DNAs isolated from tissue samples and peripheral blood, detected only wild-type sequences. Based on these results, we concluded that the patient is affected by an unusual phenotype of NF1, and that the observed unilateral overgrowth of the left leg might be a rare consequence of the identified c.5727insT mutation.

Original languageEnglish
Pages (from-to)763-766
Number of pages4
JournalClinical and Experimental Dermatology
Issue number7
Early online date8 Jun 2017
Publication statusPublished - 1 Oct 2017


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