Atypical (RIO) protein kinases from Haemonchus contortus--promise as new targets for nematocidal drugs

Bronwyn E Campbell, Peter R Boag, Andreas Hofmann, Cinzia Cantacessi, Conan K Wang, Paul Taylor, Min Hu, Zia-Ud-Din Sindhu, Alex Loukas, Paul W Sternberg, Robin B Gasser

Research output: Contribution to journalArticlepeer-review

Abstract

Almost nothing is known about atypical kinases in multicellular organisms, including parasites. Supported by information and data available for the free-living nematode, Caenorhabditis elegans, and other eukaryotes, the present article describes three RIO kinase genes, riok-1, riok-2 and riok-3, from Haemonchus contortus, one of the most important parasitic nematodes of small ruminants. Analyses of these genes and their products predict that they each play critical roles in the developmental pathways of parasitic nematodes. The findings of this review indicate prospects for functional studies of these genes in C. elegans (as a surrogate) and opportunities for the design of a novel class of nematode-specific inhibitors of RIO kinases. The latter aspect is of paramount importance, given the serious problems linked to anthelmintic resistance in parasitic nematode populations of livestock.
Original languageEnglish
Pages (from-to)338-50
Number of pages13
JournalBiotechnology Advances
Volume29
Issue number3
Early online date22 Jan 2011
DOIs
Publication statusPublished - 1 May 2011

Keywords

  • Parasite
  • Haemonchus contortus
  • RIO kinases
  • Structure
  • Relationships
  • Inferred function
  • Drug targets

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