Augmentation cystoplasty and extracellular matrix scaffolds: an ex vivo comparative study with autogenous detubularised ileum

Niall F Davis, Rory Mooney, Anthony Callanan, Hugh D Flood, Tim M McGloughlin

Research output: Contribution to journalArticlepeer-review

Abstract

Augmentation cystoplasty (AC) with autogenous ileum remains the current gold standard surgical treatment for many patients with end-stage bladder disease. However, the presence of mucus-secreting epithelium within the bladder is associated with debilitating long-term complications. Currently, decellularised biological materials derived from porcine extracellular matrix (ECM) are under investigation as potential augmentation scaffolds. Important biomechanical limitations of ECMs are decreased bladder capacity and poor compliance after implantation.
Original languageEnglish
Article numbere20323
JournalPLoS ONE
Volume6
Issue number5
DOIs
Publication statusPublished - 2011

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