Autism Traits in Individuals with Agenesis of the Corpus Callosum

Yolanda C. Lau, Leighton B. N. Hinkley, Polina Bukshpun, Zoe A. Strominger, Mari L. J. Wakahiro, Simon Baron-Cohen, Carrie Allison, Bonnie Auyeung, Rita J. Jeremy, Srikantan S. Nagarajan, Elliott H. Sherr*, Elysa J. Marco

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Autism spectrum disorders (ASD) have numerous etiologies, including structural brain malformations such as agenesis of the corpus callosum (AgCC). We sought to directly measure the occurrence of autism traits in a cohort of individuals with AgCC and to investigate the neural underpinnings of this association. We screened a large AgCC cohort (n = 106) with the Autism Spectrum Quotient (AQ) and found that 45 % of children, 35 % of adolescents, and 18 % of adults exceeded the predetermined autism-screening cut-off. Interestingly, performance on the AQ's imagination domain was inversely correlated with magnetoencephalography measures of resting-state functional connectivity in the right superior temporal gyrus. Individuals with AgCC should be screened for ASD and disorders of the corpus callosum should be considered in autism diagnostic evaluations as well.

Original languageEnglish
Pages (from-to)1106-1118
Number of pages13
JournalJournal of Autism and Developmental Disorders
Volume43
Issue number5
DOIs
Publication statusPublished - May 2013

Keywords

  • Magnetoencephalography
  • WHITE-MATTER COMPROMISE
  • SPECTRUM QUOTIENT AQ
  • SOCIAL COGNITION
  • CHILDREN
  • FUNCTIONAL CONNECTIVITY
  • Superior temporal gyrus
  • ADOLESCENTS
  • Autism spectrum disorders
  • PERVASIVE DEVELOPMENTAL DISORDERS
  • PREVALENCE
  • Agenesis of the corpus callosum
  • Autism Spectrum Quotient
  • Functional connectivity
  • SUPERIOR TEMPORAL GYRUS
  • FRAGILE-X-SYNDROME

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