Autoactivation of small GTPases by the GEF–effector positive feedback modules

Andrew Goryachev; Marcin Leda

doi:10.12688/f1000research.20003.1

Autoactivation of small GTPases by the GEF–effector positive feedback modules

Andrew Goryachev, Marcin Leda

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the localization and activation of their regulators, guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Remarkably, in some systems, the upstream regulators of GTPases are also found downstream of their activity. Resulting feedback loops can generate complex spatiotemporal dynamics of GTPases with important functional consequences. Here we discuss the concept of positive autoregulation of small GTPases by the GEF–effector feedback modules and survey recent developments in this exciting area of cell biology.

Original language	English
Journal	F1000prime reports
Early online date	23 Sep 2019
DOIs	https://doi.org/10.12688/f1000research.20003.1
Publication status	E-pub ahead of print - 23 Sep 2019

Keywords

small GTPases
Arf GTPases
Rab GTPases
Cdc42
Rho GTPases
cell biology
autoregulation
positive feedback
symmetry breaking

Access to Document

10.12688/f1000research.20003.1Licence: Creative Commons: Attribution (CC-BY)

LedaEtalF1000R2019AutoactivationOfSmallGTPasesByTheGEF–EffectorPositiveFinal published version, 905 KBLicence: Creative Commons: Attribution (CC-BY)

15 NSFBIO: Excitocell: A rewired eukaryotic cell model for the analysis and design of cellular morphogenesis
Goryachev, A.
BBSRC
1/11/17 → 31/12/20
Project: Research
Cortical excitability as a mechanism for epithelial barrier maintenance: A joint experiment-theory systems approach
Goryachev, A.
BBSRC
26/06/17 → 25/06/20
Project: Research

Cite this

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title = "Autoactivation of small GTPases by the GEF–effector positive feedback modules",

abstract = "Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the localization and activation of their regulators, guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Remarkably, in some systems, the upstream regulators of GTPases are also found downstream of their activity. Resulting feedback loops can generate complex spatiotemporal dynamics of GTPases with important functional consequences. Here we discuss the concept of positive autoregulation of small GTPases by the GEF–effector feedback modules and survey recent developments in this exciting area of cell biology.",

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N2 - Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the localization and activation of their regulators, guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Remarkably, in some systems, the upstream regulators of GTPases are also found downstream of their activity. Resulting feedback loops can generate complex spatiotemporal dynamics of GTPases with important functional consequences. Here we discuss the concept of positive autoregulation of small GTPases by the GEF–effector feedback modules and survey recent developments in this exciting area of cell biology.

AB - Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the localization and activation of their regulators, guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Remarkably, in some systems, the upstream regulators of GTPases are also found downstream of their activity. Resulting feedback loops can generate complex spatiotemporal dynamics of GTPases with important functional consequences. Here we discuss the concept of positive autoregulation of small GTPases by the GEF–effector feedback modules and survey recent developments in this exciting area of cell biology.

KW - small GTPases

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KW - Rab GTPases

KW - Cdc42

KW - Rho GTPases

KW - cell biology

KW - autoregulation

KW - positive feedback

KW - symmetry breaking

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DO - 10.12688/f1000research.20003.1

M3 - Article

JO - F1000prime reports

JF - F1000prime reports

SN - 2051-7599

ER -

Autoactivation of small GTPases by the GEF–effector positive feedback modules

Abstract

Keywords

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Projects

15 NSFBIO: Excitocell: A rewired eukaryotic cell model for the analysis and design of cellular morphogenesis

Cortical excitability as a mechanism for epithelial barrier maintenance: A joint experiment-theory systems approach

Cite this