Autoactivation of small GTPases by the GEF–effector positive feedback modules

Research output: Contribution to journalArticlepeer-review


Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the localization and activation of their regulators, guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Remarkably, in some systems, the upstream regulators of GTPases are also found downstream of their activity. Resulting feedback loops can generate complex spatiotemporal dynamics of GTPases with important functional consequences. Here we discuss the concept of positive autoregulation of small GTPases by the GEF–effector feedback modules and survey recent developments in this exciting area of cell biology.
Original languageEnglish
JournalF1000prime reports
Early online date23 Sep 2019
Publication statusE-pub ahead of print - 23 Sep 2019


  • small GTPases
  • Arf GTPases
  • Rab GTPases
  • Cdc42
  • Rho GTPases
  • cell biology
  • autoregulation
  • positive feedback
  • symmetry breaking


Dive into the research topics of 'Autoactivation of small GTPases by the GEF–effector positive feedback modules'. Together they form a unique fingerprint.

Cite this