Automated image analysis for high-throughput quantitative detection of ER and PR expression levels in large-scale clinical studies: the TEAM Trial Experience

Dana Faratian, Charlene Kay, Tammy Robson, Fiona M Campbell, Margaret Grant, Dan Rea, John M S Bartlett

Research output: Contribution to journalArticlepeer-review

Abstract

Routine immunohistochemistry is regarded as a semiquantitative method for the evaluation of in situ protein expression. Analysis of tissue biomarkers in large clinical trials is central to the development of novel targeted approaches to therapy, requires the analysis of tens of thousands of data points, and frequently makes use of high-throughput analysis of tissue microarrays (TMAs). The aim of this study was to investigate the potential of image analysis for accurate and reproducible quantitative evaluation of biomarkers.
Original languageEnglish
Pages (from-to)587-93
Number of pages7
JournalHistopathology
Volume55
Issue number5
DOIs
Publication statusPublished - Nov 2009

Fingerprint Dive into the research topics of 'Automated image analysis for high-throughput quantitative detection of ER and PR expression levels in large-scale clinical studies: the TEAM Trial Experience'. Together they form a unique fingerprint.

Cite this