Axl and mer receptor tyrosine kinases: Distinct and nonoverlapping roles in inflammation and cancer?

Ian Dransfield*, Sarah Farnworth

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The receptor tyrosine kinases Axl and Mer subserve the process of termination of proinflammatory signaling and have key roles in both the resolution of inflammation and restoration of homeostasis. Axl functions prominently under conditions of tissue stress or in response to infection, whereas Mer has a major role in maintenance of homeostasis within tissues. Distinct patterns of expression of Axl and Mer underlie their clearly defined functional roles during the initiation and progression of inflammation. Axl and Mer are expressed by tumor cells and by infiltrating inflammatory cells and the regulation of cellular function via Axl and Mer signaling is also important for tumorigenesis, tumor progression, and metastasis. In this review, we consider the divergent functions of Axl and Mer in the context of inflammatory processes within tumors and the implications for development of therapeutic agents targeting these receptors.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages113-132
Number of pages20
Volume930
DOIs
Publication statusPublished - 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume930
ISSN (Print)00652598
ISSN (Electronic)22148019

Keywords

  • Axl
  • Gas6
  • Homeostasis
  • Inflammation
  • Macrophage
  • Mer
  • Protein S
  • Receptor tyrosine kinase
  • Tumor
  • Tumor microenvironment

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