B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial

VITATOPS Trial Study Group, Martin Dennis

Research output: Contribution to journalArticlepeer-review

Abstract

Epidemiological studies suggest that raised plasma concentrations of total homocysteine might be a risk factor for major vascular events. Whether lowering total homocysteine with B vitamins prevents major vascular events in patients with previous stroke or transient ischaemic attack is unknown. We aimed to assess whether the addition of once-daily supplements of B vitamins to usual medical care would lower total homocysteine and reduce the combined incidence of non-fatal stroke, non-fatal myocardial infarction, and death attributable to vascular causes in patients with recent stroke or transient ischaemic attack of the brain or eye.
Original languageEnglish
Pages (from-to)855-65
Number of pages11
JournalLancet Neurology
Volume9
Issue number9
DOIs
Publication statusPublished - 2010

Keywords

  • Aged
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • International Cooperation
  • Ischemic Attack, Transient
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Prospective Studies
  • Severity of Illness Index
  • Stroke
  • Treatment Outcome
  • Vitamin B Complex

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