Balance equations can buffer noisy and sustained environmental perturbations of circadian clocks

Mirela Domijan, David A Rand, Karen Halliday (Group Leader)

Research output: Contribution to journalArticlepeer-review

Abstract

We present a new approach to understanding how regulatory networks such as circadian clocks might evolve robustness to environmental fluctuations. The approach is in terms of new balance equations that we derive. We use it to describe how an entrained clock can buffer the effects of daily fluctuations in light and temperature levels. We also use it to study a different approach to temperature compensation where instead of considering a free-running clock, we study temperature buffering of the phases in a light-entrained clock, which we believe is a more physiological setting.
Original languageEnglish
Pages (from-to)177-186
Number of pages10
JournalInterface Focus
Volume1
Issue number1
Early online date1 Dec 2010
DOIs
Publication statusPublished - 6 Feb 2011

Keywords

  • balance equations
  • environmental perturbations
  • circadian clocks
  • mathematical models
  • sensitivity analysis
  • robustness

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