Projects per year
Abstract / Description of output
A convenient method for the synthesis of bicyclic 4-aminopyrimidines is described, involving the reaction of dinitriles with mononitriles in the presence of catalytic potassium tert-butoxide. These reactions proceed via the Thorpe-Ziegler cyclization of the dinitrile to form an intermediate beta-cyanoenamine, which then undergoes annulation with the mononitrile in situ. (C) 2011 Elsevier Ltd. All rights reserved.
Original language | English |
---|---|
Pages (from-to) | 3839-3845 |
Number of pages | 7 |
Journal | Tetrahedron |
Volume | 67 |
Issue number | 21 |
DOIs | |
Publication status | Published - 27 May 2011 |
Keywords / Materials (for Non-textual outputs)
- 4-Aminopyrimidine
- Dinitrile
- Nitrile
- Cyclization
- Base catalysis
- RECEPTOR ANTAGONISTS
- NITRILES
- CONDENSATION
Fingerprint
Dive into the research topics of 'Base-catalyzed synthesis of bicyclic 4-aminopyrimidines from the reaction of dinitriles with mononitriles'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Transition-metal catalysed cycloaddition methodology for the convergent asembly of (Hetero) aromatic compounds
Lam, H.
1/10/08 → 30/09/11
Project: Research