Basic DNA electrophoresis in molecular cloning: a comprehensive guide for beginners

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract / Description of output

Presented here is a complete molecular cloning protocol consisting of a number of separate but interconnected methods such as preparation of E. coli competent cells; in vitro DNA digestion and ligation; PCR; DNA agarose gel electrophoresis and gel extraction; and screening transformants by colony PCR, analytical restriction digests, and sequencing. The method is described in a lot of details so that it can be easily followed by those with very little relevant knowledge and skills. It also contains many tips that even experienced researchers may find useful.
Original languageEnglish
Title of host publicationDNA Electrophoresis
Place of PublicationTotowa, NJ
PublisherHumana Press
Chapter2
Pages11-43
Number of pages33
ISBN (Electronic)978-1-62703-565-1
ISBN (Print)978-1-62703-564-4
DOIs
Publication statusPublished - 2013

Publication series

NameMethods in Molecular Biology
PublisherHumana Press
Volume1054
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords / Materials (for Non-textual outputs)

  • Cloning
  • Agarose gel electrophoresis
  • DNA gel extraction
  • Competent cells
  • Clone screening
  • Restriction enzymes
  • Ligation

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