BCL2 gene abnormalities define distinct clinical subsets of follicular lymphoma

J R Goodlad, P J Batstone, D A Hamilton, N M Kernohan, D A Levison, J M White

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

AIMS: Follicular lymphoma (FL) arising primarily in the skin has recently been proposed as a distinct entity on the basis of a low incidence of t(14;18)(q32;q21) and bcl-2 expression, with a very high percentage of patients surviving more than 5 years. However, cases of t(14;18)(q32;q21)-positive primary cutaneous FL (PCFL) and examples of t(14;18)(q32;q21)-negative FL at nodal and other extranodal sites, are well documented. The aim of this study was to test the hypothesis that there is a subtype of FL lacking t(14;18)(q32;q21), which preferentially involves certain sites but is not restricted by anatomical location.

METHODS AND RESULTS: A cohort of 47 stage 1 FL was stratified according to the presence or absence of t(14;18)(q32;q21) using conventional cytogenetics, polymerase chain reaction and interphase fluorescence in situ hybridization. Compared with t(14;18)(q32;q21)-positive cases, FL lacking the translocation were less likely to express CD10 or bcl-2 (P<0.01), made up a significantly greater proportion of cases arising at extranodal sites (P<0.001) and had a significantly better overall and disease-specific 5-year survival (P<0.01).

CONCLUSIONS: These results support the concept of a subtype of FL lacking t(14;18)(q32;q21), characterized by low-intensity bcl-2 expression, a predilection for extranodal sites, particularly the skin, and a more favourable outcome than t(14;18)(q32;q21)-positive FL.

Original languageEnglish
Pages (from-to)229-41
Number of pages13
JournalHistopathology
Volume49
Issue number3
DOIs
Publication statusPublished - Sept 2006

Keywords / Materials (for Non-textual outputs)

  • Adult
  • Aged
  • Aged, 80 and over
  • Chromosome Aberrations
  • Chromosomes, Human, Pair 14
  • Chromosomes, Human, Pair 18
  • Female
  • Genes, bcl-2
  • Humans
  • In Situ Hybridization, Fluorescence
  • Lymphoma, Follicular
  • Male
  • Middle Aged
  • Neprilysin
  • Polymerase Chain Reaction
  • Prognosis
  • Proto-Oncogene Proteins c-bcl-2
  • Survival Analysis
  • Translocation, Genetic

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