Behavioral tagging and capture: long-term memory decline in middle-aged rats

Alexandra Gros, Szu-Han Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Decline in cognitive functions, including hippocampus-dependent spatial memory, is commonly observed at a later stage of aging (e.g., >20 months old in rodents) and typically studied after a discrete learning event. How normal aging, particularly at an early stage, affects the modulatory aspect of memory persistence is underinvestigated. Previous studies in young animals show that weak, fading memories can last longer if a modulating event, such as spatial novelty, is introduced around memory encoding. This is known as behavioral tagging and capture (BTC). Here, we investigated how early aging (10-13 months old) affects BTC in an appetitive delayed-matching-to-place task. We trained rats when they were young and middle aged and found that novelty facilitated long-term memory persistence in young but not in middle-aged rats. However, re-exposure to the encoded environment after learning improved memory persistence in middle-aged rats. BTC, combined with memory reactivation, facilitated memory persistence through reconsolidation. Our results point toward a weakened tagging and capture mechanism before reduction of plasticity-related proteins at an early stage of aging.

Original languageEnglish
Pages (from-to)31-41
Number of pages11
JournalNeurobiology of Aging
Volume67
Early online date10 Mar 2018
DOIs
Publication statusE-pub ahead of print - 10 Mar 2018

Keywords

  • Journal Article

Fingerprint

Dive into the research topics of 'Behavioral tagging and capture: long-term memory decline in middle-aged rats'. Together they form a unique fingerprint.

Cite this