Benign focal liver lesions: spectrum of findings on SonoVue-enhanced pulse-inversion ultrasonography

Tommaso Vincenzo Bartolotta, Massimo Midiri, Emilio Quaia, Michele Bertolotto, Massimo Galia, Filippo Cademartiri, Roberto Lagalla, Adelfio Elio Cardinale

Research output: Contribution to journalArticlepeer-review


The prevalence of benign focal liver lesions (BFLL) is high both in the general population and in patients with known malignancies. The gray-scale ultrasound (US) technique is usually the first-line imaging modality used in the radiological workup of such lesions, but unfortunately it lacks specificity. Furthermore, Doppler examination may often be unsatisfactory owing to motion artefacts, or when small or deeply located lesions are evaluated. Recently, microbubble-based contrast agents used in combination with gray-scale US techniques, which are very sensitive to nonlinear behavior of microbubbles, have led to a better depiction of both microvasculature and macrovasculature of focal hepatic masses, thus improving the reliability of using US in the assessment of liver tumors. This review illustrates the spectrum of enhancement patterns of BFLL on contrast-enhanced ultrasonography with SonoVue, a second-generation microbubble-based contrast agent.

Original languageEnglish
Pages (from-to)1643-9
Number of pages7
JournalEuropean Radiology
Issue number8
Publication statusPublished - Aug 2005


  • Adenoma, Liver Cell
  • Contrast Media
  • Female
  • Focal Nodular Hyperplasia
  • Hemangioma
  • Humans
  • Liver Diseases
  • Liver Neoplasms
  • Male
  • Phospholipids
  • Sulfur Hexafluoride


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