James W. Dear, D. Nicholas Bateman

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Benzodiazepine compounds are rarely fatal if ingested alone but will potentiate central nervous system depression caused by co-ingested medication. Although an antagonist, flumazenil, is available, its use in overdose is associated with potential hazard, particularly the risk of precipitating convulsions or withdrawal if given in excess to those who have co-ingested a pro-convulsant, who take benzodiazepines regularly or who are known epileptic patients. Routine use in all cases is therefore not advised, and indications are restricted to patients who develop reduced ventilation and coma and who otherwise would require mechanical ventilation and have not ingested tricyclic antidepressants or other pro-convulsants, including cocaine.

Original languageEnglish
Pages (from-to)145
Number of pages1
Issue number3
Early online date6 Feb 2016
Publication statusPublished - 1 Mar 2016

Keywords / Materials (for Non-textual outputs)

  • Benzodiazepines
  • diazepam
  • flumazenil
  • zolpidem
  • zopiclone


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