Bilateral non-contiguous atypical papillary glioneuronal tumor: case report

Thomas Flannery, Andrew Purce, Jacqueline Harney, Steven McKinstry, James W Ironside, Brian Herron

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Papillary glioneuronal tumor (PGNT) was first described as a distinct clinic-pathological entity by Komori et al. in 1998. Since then it has been included as a mixed neuronal-glial tumor in the revised WHO (2007) classification of central nervous system tumors. On brain imaging, it appears as a demarcated, solid to cystic, contrast-enhancing mass usually located in the temporal lobe. Histologically, it is considered a biphasic tumor characterized by small cuboidal GFAP-positive astrocytes around hyalinised blood vessels and synaptophysin-positive interpapillary collections of neurocytes, large neurons and intermediate-sized "ganglioid cells". Although they are generally regarded as benign WHO Grade I tumors, recent reports have described more pathologically aggressive features. To date, these reports have all been single lesions.
Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalClinical neuropathology
Issue number2
Publication statusPublished - 2013


  • Brain Neoplasms
  • Astrocytes
  • Neurons
  • Humans
  • Temporal Lobe
  • Middle Aged
  • Glial Fibrillary Acidic Protein
  • Glioma
  • Female


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