Binding Inhibitors of the Beta-Transducin Repeat-Containing Protein

Mark Bradley (Inventor), Jeffrey Walton (Inventor), Sunay Chankeshwara (Inventor), Mazen Haj Sleiman (Inventor), G. S. Baillie (Inventor), Lucien Gibson (Inventor)

Research output: Patent

Abstract

The present invention relates to compounds which bind to Beta Trans-ducin repeat-containing protein (PTrCP), and modulate the activity of l3TrCP. In particular, the invention relates to compounds which demonstrate optimised binding to PTrCP. The invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds as medicaments, specifically for the treatment of disorders associated with aberrant protein degradation, such as cancer. The preferred binding inhibitors are peptides derived from the motive DSGXXS, e.g. DEGFWE, DDGFWD and Succinyl-EGFWE.
Original languageEnglish
Patent numberWO 2013/001297
IPCC07K 7/06 (2006.01), C07K 14/47 (2006.01)
Priority date27/06/11
Publication statusPublished - 3 Jan 2013

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