Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments

Erik A Johannessen; Lei Wang; Cathy Wyse; David R S Cumming; Jon M Cooper

doi:10.1109/TBME.2006.883698

Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments

Erik A Johannessen, Lei Wang, Cathy Wyse, David R S Cumming, Jon M Cooper^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

In this paper, we present a radiotelemetry sensor, designed as a lab-in-a-pill, which incorporates a two-channel microfabricated sensor platform for real-time measurements of temperature and pH. These two parameters have potential application for use in remote biological sensing (for example they may be used as markers that reflect the physiological environment or as indicators for disease, within the gastrointestinal tract). We have investigated the effects of biofouling on these sensors, by exploring their response time and sensitivity in a model in vitro gastrointestinal system. The artificial gastric and intestinal solutions used represent a model both for fasting, as well as for the ingestion of food and subsequent digestion to gastrointestinal chyme. The results showed a decrease in pH sensitivity after exposure of the sensors for 3 h. The response time also increased from an initial measurement time of 10 s in pure GI juice, to ca. 25 s following the ingestion of food and 80 s in simulated chyme. These in vitro results indicate that changes in viscosity in our model gastrointestinal system had a pronounced effect on the unmodified sensor.

Original language	English
Pages (from-to)	2333-40
Number of pages	8
Journal	IEEE Transactions on Biomedical Engineering
Volume	53
Issue number	11
DOIs	https://doi.org/10.1109/TBME.2006.883698
Publication status	Published - 30 Nov 2006

Keywords / Materials (for Non-textual outputs)

Biocompatible Materials/analysis
Biomimetic Materials
Equipment Design
Equipment Failure Analysis
Gastrointestinal Contents/chemistry
Gastrointestinal Tract/chemistry
Hydrogen-Ion Concentration
Ion-Selective Electrodes
Prostheses and Implants
Reproducibility of Results
Sensitivity and Specificity
Telemetry/instrumentation
Thermography/instrumentation
Transducers

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10.1109/TBME.2006.883698

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title = "Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments",

abstract = "In this paper, we present a radiotelemetry sensor, designed as a lab-in-a-pill, which incorporates a two-channel microfabricated sensor platform for real-time measurements of temperature and pH. These two parameters have potential application for use in remote biological sensing (for example they may be used as markers that reflect the physiological environment or as indicators for disease, within the gastrointestinal tract). We have investigated the effects of biofouling on these sensors, by exploring their response time and sensitivity in a model in vitro gastrointestinal system. The artificial gastric and intestinal solutions used represent a model both for fasting, as well as for the ingestion of food and subsequent digestion to gastrointestinal chyme. The results showed a decrease in pH sensitivity after exposure of the sensors for 3 h. The response time also increased from an initial measurement time of 10 s in pure GI juice, to ca. 25 s following the ingestion of food and 80 s in simulated chyme. These in vitro results indicate that changes in viscosity in our model gastrointestinal system had a pronounced effect on the unmodified sensor.",

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author = "Johannessen, \{Erik A\} and Lei Wang and Cathy Wyse and Cumming, \{David R S\} and Cooper, \{Jon M\}",

year = "2006",

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doi = "10.1109/TBME.2006.883698",

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AU - Johannessen, Erik A

AU - Wang, Lei

AU - Wyse, Cathy

AU - Cumming, David R S

AU - Cooper, Jon M

PY - 2006/11/30

Y1 - 2006/11/30

N2 - In this paper, we present a radiotelemetry sensor, designed as a lab-in-a-pill, which incorporates a two-channel microfabricated sensor platform for real-time measurements of temperature and pH. These two parameters have potential application for use in remote biological sensing (for example they may be used as markers that reflect the physiological environment or as indicators for disease, within the gastrointestinal tract). We have investigated the effects of biofouling on these sensors, by exploring their response time and sensitivity in a model in vitro gastrointestinal system. The artificial gastric and intestinal solutions used represent a model both for fasting, as well as for the ingestion of food and subsequent digestion to gastrointestinal chyme. The results showed a decrease in pH sensitivity after exposure of the sensors for 3 h. The response time also increased from an initial measurement time of 10 s in pure GI juice, to ca. 25 s following the ingestion of food and 80 s in simulated chyme. These in vitro results indicate that changes in viscosity in our model gastrointestinal system had a pronounced effect on the unmodified sensor.

AB - In this paper, we present a radiotelemetry sensor, designed as a lab-in-a-pill, which incorporates a two-channel microfabricated sensor platform for real-time measurements of temperature and pH. These two parameters have potential application for use in remote biological sensing (for example they may be used as markers that reflect the physiological environment or as indicators for disease, within the gastrointestinal tract). We have investigated the effects of biofouling on these sensors, by exploring their response time and sensitivity in a model in vitro gastrointestinal system. The artificial gastric and intestinal solutions used represent a model both for fasting, as well as for the ingestion of food and subsequent digestion to gastrointestinal chyme. The results showed a decrease in pH sensitivity after exposure of the sensors for 3 h. The response time also increased from an initial measurement time of 10 s in pure GI juice, to ca. 25 s following the ingestion of food and 80 s in simulated chyme. These in vitro results indicate that changes in viscosity in our model gastrointestinal system had a pronounced effect on the unmodified sensor.

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KW - Biomimetic Materials

KW - Equipment Design

KW - Equipment Failure Analysis

KW - Gastrointestinal Contents/chemistry

KW - Gastrointestinal Tract/chemistry

KW - Hydrogen-Ion Concentration

KW - Ion-Selective Electrodes

KW - Prostheses and Implants

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Telemetry/instrumentation

KW - Thermography/instrumentation

KW - Transducers

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DO - 10.1109/TBME.2006.883698

M3 - Article

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SN - 0018-9294

VL - 53

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EP - 2340

JO - IEEE Transactions on Biomedical Engineering

JF - IEEE Transactions on Biomedical Engineering

IS - 11

ER -

Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments

Abstract

Keywords / Materials (for Non-textual outputs)

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