Bioequivalence of two tablet formulations of capecitabine and exploration of age, gender, body surface area, and creatinine clearance as factors influencing systemic exposure in cancer patients

J Cassidy, C Twelves, D Cameron, W Steward, K O'Byrne, D Jodrell, L Banken, T Goggin, D Jones, B Roos, E Bush, E Weidekamm, B Reigner

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The objective of the study was to assess the bioequivalence of two tablet formulations of capecitabine and to explore the effect of age, gender, body surface area and creatinine clearance on the systemic exposure to capecitabine and its metabolites.
Original languageEnglish
Pages (from-to)453-60
Number of pages8
JournalCancer chemotherapy and pharmacology
Volume44
Issue number6
Publication statusPublished - 1999

Keywords / Materials (for Non-textual outputs)

  • Analysis of Variance
  • Antineoplastic Agents
  • Area Under Curve
  • Biotransformation
  • Body Surface Area
  • Confidence Intervals
  • Creatinine
  • Cross-Over Studies
  • Deoxycytidine
  • Female
  • Fluorouracil
  • Half-Life
  • Humans
  • Male
  • Metabolic Clearance Rate
  • Neoplasms
  • Regression Analysis
  • Sex Characteristics
  • Tablets
  • Therapeutic Equivalency

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