Abstract
A method of preparing an active agent or a salt thereof from a prodrug first compound (1) comprising a propargyl group connected to an oxygen that is directly or indirectly connected to the active agent is provided, wherein the bond between the propargyl group and the oxygen is cleaved by reacting the first compound with palladium or gold, thereby releasing the active agent. Prodrug compositions suitable for use in the method are also provided.
| Original language | English |
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| Patent number | WO/2017/199028 |
| IPC | C07H 15/252 (2006.01), C07H 19/06 (2006.01), C07H 17/08 (2006.01), A61K 31/12 (2006.01), A61K 31/417 (2006.01), A61K 31/437 (2006.01), A61K 31/496 (2006.01), A61K 31/513 (2006.01), A61K 31/704 (2006.01), C07C 259/06 (2006.01), A61K 31/7048 (2006.01), C07D 233/64 (2006.01), C07D 237/32 (2006.01), C07D 239/52 (2006.01), C07D 491/147 (2006.01) |
| Priority date | 18/05/16 |
| Publication status | Published - 23 Nov 2017 |