Bioorthogonal Swarming: In Situ Generation of Dendrimers

Yichuan Zhang, Muhammed Üçüncü, Alessia Gambardella, Assel Baibek, Jin Geng, Shuo Zhang, Jessica Clavadetscher, Inga Litzen, Mark Bradley, Annamaria Lilienkampf

Research output: Contribution to journalArticlepeer-review

Abstract

With the aid of bioorthogonal chemistry, we demonstrate the fabrication of synthetic dendrimers in situ around living cells. Using tetrazine dienophile and aminooxyl/hydrazide aldehyde chemistries, the density of functional groups on the dendrimers exponentially amplified intensities of fluorescent markers in antibody-targeted live cell imaging. This novel "swarming"approach highlights the power of bioorthogonal chemistry and provides a route to non-natural chemical structures on cells, paving the way for the generation of various artificial cellular nanostructures and scaffolds.

Original languageEnglish
Pages (from-to)21615–21621
Number of pages7
JournalJournal of the American Chemical Society
Volume142
Issue number52
Early online date16 Dec 2020
DOIs
Publication statusPublished - 30 Dec 2020

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