Biophysical properties of presynaptic short-term plasticity in hippocampal neurons: insights from electrophysiology, imaging and mechanistic models

Ranjita Dutta Roy, Melanie I. Stefan, Christian Rosenmund*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Hippocampal neurons show different types of short-term plasticity (SIP). Some exhibit facilitation of their synaptic responses and others depression. In this review we discuss presynaptic biophysical properties behind heterogeneity in SIP in hippocampal neurons such as alterations in vesicle priming and docking, fusion, neurotransmitter filling and vesicle replenishment. We look into what types of information electrophysiology, imaging and mechanistic models have given about the time scales and relative impact of the different properties on SIP with an emphasis on the use of mechanistic models as complementary tools to experimental procedures. Taken together this tells us that it is possible for a multitude of different mechanisms to underlie the same SIP pattern, even though some are more important in specific cases, and that mechanistic models can be used to integrate the biophysical properties to see which mechanisms are more important in specific cases of SIR

Original languageEnglish
Article number141
Number of pages9
JournalFrontiers in Cellular Neuroscience
Volume8
DOIs
Publication statusPublished - 22 May 2014

Keywords

  • short-termplasticity
  • vesicle dynamics
  • hippocampal neurons
  • biophysical models
  • imaging
  • electrophysiology
  • FROG NEUROMUSCULAR JUNCTION
  • SYNAPTIC VESICLE DOCKING
  • READILY RELEASABLE POOL
  • TRANSMITTER RELEASE
  • CENTRAL SYNAPSES
  • NEUROTRANSMITTER RELEASE
  • MOLECULAR-MECHANISMS
  • ACTIVE ZONE
  • RAT CALYX
  • CALCIUM

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