Biosensors in bioprocess monitoring and control: Current trends and future prospects

Chris French, Marco Cardosi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Fermentation processes are complex systems, with many interacting variables. Continuous monitoring of parameters such as pH, temperature, and dissolved oxygen levels, with direct feedback to control systems, is standard even in the smallest bioreactors and the enabling technologies are well established. Monitoring of other parameters, such as the levels of substrates and products, is also extremely useful but presents greater difficulties. Products and metabolites can be monitored off-line by analysing samples using techniques such as HPLC, GC or ELISA, but this presents inevitable delays. In this chapter, we will examine the potential benefits offered by biosensors for process monitoring.
Original languageEnglish
Title of host publicationFermentation Microbiology and Biotechnology
EditorsMansi El-Mansi, Charlie Bryce, Arnold Demain, Tony Allman
Place of PublicationBoca Raton, FL
PublisherCRC PRESS-TAYLOR & FRANCIS GROUP
Pages363-406
Number of pages44
Edition2
ISBN (Print)0-8493-5334-3, 978-0-8493-5334-5
Publication statusPublished - 2007

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