Birth of the snoRNPs: the evolution of RNase MRP and the eukaryotic pre-rRNA-processing system

John P. Morrissey*, David Tollervey

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The ribonucleoprotein particle RNase MRP is required for the processing of yeast pre-ribosomal RNA (pre-rRNA). A structurally related particle, RNase P, is universally required for processing of pre-tRNA, but in bacteria are archaea also cleaves a site in the pre-rRNA. This suggests that RNase MRP may have arisen in eukaryotes as a form of RNase P specialized for pre-rRNA processing. Other eukaryotic small nucleolar RNAs may have arisen as trans-acting factors that functionally replace cis-acting pre-rRNA interactions in bacteria and archaea.

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalTrends in biochemical sciences
Volume20
Issue number2
DOIs
Publication statusPublished - Feb 1995

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