Birth of the snoRNPs: the evolution of RNase MRP and the eukaryotic pre-rRNA-processing system

John P. Morrissey; David Tollervey

doi:10.1016/S0968-0004(00)88962-8

Birth of the snoRNPs: the evolution of RNase MRP and the eukaryotic pre-rRNA-processing system

John P. Morrissey^*, David Tollervey

^*Corresponding author for this work

School of Biological Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

The ribonucleoprotein particle RNase MRP is required for the processing of yeast pre-ribosomal RNA (pre-rRNA). A structurally related particle, RNase P, is universally required for processing of pre-tRNA, but in bacteria are archaea also cleaves a site in the pre-rRNA. This suggests that RNase MRP may have arisen in eukaryotes as a form of RNase P specialized for pre-rRNA processing. Other eukaryotic small nucleolar RNAs may have arisen as trans-acting factors that functionally replace cis-acting pre-rRNA interactions in bacteria and archaea.

Original language	English
Pages (from-to)	78-82
Number of pages	5
Journal	Trends in biochemical sciences
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/S0968-0004(00)88962-8
Publication status	Published - Feb 1995

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title = "Birth of the snoRNPs: the evolution of RNase MRP and the eukaryotic pre-rRNA-processing system",

abstract = "The ribonucleoprotein particle RNase MRP is required for the processing of yeast pre-ribosomal RNA (pre-rRNA). A structurally related particle, RNase P, is universally required for processing of pre-tRNA, but in bacteria are archaea also cleaves a site in the pre-rRNA. This suggests that RNase MRP may have arisen in eukaryotes as a form of RNase P specialized for pre-rRNA processing. Other eukaryotic small nucleolar RNAs may have arisen as trans-acting factors that functionally replace cis-acting pre-rRNA interactions in bacteria and archaea.",

author = "Morrissey, {John P.} and David Tollervey",

year = "1995",

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AU - Tollervey, David

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N2 - The ribonucleoprotein particle RNase MRP is required for the processing of yeast pre-ribosomal RNA (pre-rRNA). A structurally related particle, RNase P, is universally required for processing of pre-tRNA, but in bacteria are archaea also cleaves a site in the pre-rRNA. This suggests that RNase MRP may have arisen in eukaryotes as a form of RNase P specialized for pre-rRNA processing. Other eukaryotic small nucleolar RNAs may have arisen as trans-acting factors that functionally replace cis-acting pre-rRNA interactions in bacteria and archaea.

AB - The ribonucleoprotein particle RNase MRP is required for the processing of yeast pre-ribosomal RNA (pre-rRNA). A structurally related particle, RNase P, is universally required for processing of pre-tRNA, but in bacteria are archaea also cleaves a site in the pre-rRNA. This suggests that RNase MRP may have arisen in eukaryotes as a form of RNase P specialized for pre-rRNA processing. Other eukaryotic small nucleolar RNAs may have arisen as trans-acting factors that functionally replace cis-acting pre-rRNA interactions in bacteria and archaea.

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DO - 10.1016/S0968-0004(00)88962-8

M3 - Review article

C2 - 7701567

AN - SCOPUS:0028983910

SN - 0968-0004

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JO - Trends in biochemical sciences

JF - Trends in biochemical sciences

IS - 2

ER -

Birth of the snoRNPs: the evolution of RNase MRP and the eukaryotic pre-rRNA-processing system

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