BISC: Binary SubComplexes in proteins database

Thomas Juettemann; Dietlind L. Gerloff

doi:10.1093/nar/gkq859

BISC: Binary SubComplexes in proteins database

Thomas Juettemann, Dietlind L. Gerloff

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Binary subcomplexes in proteins database (BISC) is a new protein-protein interaction (PPI) database linking up the two communities most active in their characterization: structural biology and functional genomics researchers. The BISC resource offers users (i) a structural perspective and related information about binary subcomplexes (i.e. physical direct interactions between proteins) that are either structurally characterized or modellable entries in the main functional genomics PPI databases BioGRID, IntAct and HPRD; (ii) selected web services to further investigate the validity of postulated PPI by inspection of their hypothetical modelled interfaces. Among other uses we envision that this resource can help identify possible false positive PPI in current database records. BISC is freely available at http://bisc.cse.ucsc.edu.

Original language	English
Pages (from-to)	D705-D711
Number of pages	7
Journal	Nucleic Acids Research
Volume	39
Issue number	suppl 1
Early online date	16 Nov 2010
DOIs	https://doi.org/10.1093/nar/gkq859
Publication status	Published - 1 Jan 2011

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BISC: Binary SubComplexes in proteins database

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