BISC: Binary SubComplexes in proteins database

Thomas Juettemann, Dietlind L. Gerloff

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Binary subcomplexes in proteins database (BISC) is a new protein-protein interaction (PPI) database linking up the two communities most active in their characterization: structural biology and functional genomics researchers. The BISC resource offers users (i) a structural perspective and related information about binary subcomplexes (i.e. physical direct interactions between proteins) that are either structurally characterized or modellable entries in the main functional genomics PPI databases BioGRID, IntAct and HPRD; (ii) selected web services to further investigate the validity of postulated PPI by inspection of their hypothetical modelled interfaces. Among other uses we envision that this resource can help identify possible false positive PPI in current database records. BISC is freely available at

Original languageEnglish
Pages (from-to)D705-D711
Number of pages7
JournalNucleic Acids Research
Issue numbersuppl 1
Early online date16 Nov 2010
Publication statusPublished - 1 Jan 2011


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