Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease

Salvatore Rudilosso; Michael S Stringer; Michael Thrippleton; Francesca Chappell; Gordon W Blair; Daniela Jaime garcia; Fergus Doubal; Iona Hamilton; Esther Janssen; Anna Kopczak; Michael Ingrisch; Danielle Kerkhofs; Walter H Backes; Julie Staals; Marco Duering; Martin Dichgans; Joanna M Wardlaw

doi:10.1177/0271678X231173444

Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease

Salvatore Rudilosso, Michael S Stringer, Michael Thrippleton, Francesca Chappell, Gordon W Blair, Daniela Jaime garcia, Fergus Doubal, Iona Hamilton, Esther Janssen, Anna Kopczak, Michael Ingrisch, Danielle Kerkhofs, Walter H Backes, Julie Staals, Marco Duering, Martin Dichgans, Joanna M Wardlaw^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	0271678X2311734
Journal	Journal of Cerebral Blood Flow and Metabolism
DOIs	https://doi.org/10.1177/0271678X231173444
Publication status	Published - 3 May 2023

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10.1177/0271678X231173444

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http://journals.sagepub.com/doi/10.1177/0271678X231173444

Cite this

Rudilosso, S., Stringer, M. S., Thrippleton, M., Chappell, F., Blair, G. W., Jaime garcia, D., Doubal, F., Hamilton, I., Janssen, E., Kopczak, A., Ingrisch, M., Kerkhofs, D., Backes, W. H., Staals, J., Duering, M., Dichgans, M., & Wardlaw, J. M. (2023). Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease. Journal of Cerebral Blood Flow and Metabolism, 0271678X2311734. https://doi.org/10.1177/0271678X231173444

@article{e2eefc3612bc43068372f68305fde814,

title = "Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease",

author = "Salvatore Rudilosso and Stringer, {Michael S} and Michael Thrippleton and Francesca Chappell and Blair, {Gordon W} and {Jaime garcia}, Daniela and Fergus Doubal and Iona Hamilton and Esther Janssen and Anna Kopczak and Michael Ingrisch and Danielle Kerkhofs and Backes, {Walter H} and Julie Staals and Marco Duering and Martin Dichgans and Wardlaw, {Joanna M}",

note = "Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: SR receives funding from Instituto de Salud Carlos III, with a grant for health research and a mobility grant (CM18/00116; RH041992; JR21/00011). INVESTIGATE@SVDs is funded by the European Union Horizon 2020, PHC-03-15, Project No. 666881, “SVDs@target{\textquoteright}. This study was also supported by the Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease, Ref. No. 16 CVD 05: The Row Fogo Charitable Trust; The Row Fogo Centre for Research into Ageing and the Brain, Ref. No.: AD.ROW4.35. BRO-D.FID3668413; the Stroke Association Princess Margaret Research Development Fellowship scheme (GWB); the Stroke Association Garfield Weston Foundation Senior Clinical Lectureship and NHS Research Scotland (FND); the NHS Lothian Research and Development Office (MJT); the UK Dementia Research Institute which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society and Alzheimer's Research UK (JMW, DJG); and the Edinburgh 3T MRI scanner is funded by the Wellcome Trust (104916/Z/14/Z), Dunhill Trust (R380R/1114), the Edinburgh and Lothians Health Foundation (2012/17), the Muir Maxwell Research Fund, and the University of Edinburgh. The procurement of the MRI scanner in Munich was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) grant for major research instrumentation (DFG, INST 409/193-1 FUGG). For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. Acknowledgements Publisher Copyright: {\textcopyright} The Author(s) 2023.",

year = "2023",

month = may,

day = "3",

doi = "10.1177/0271678X231173444",

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Rudilosso, S, Stringer, MS , Thrippleton, M , Chappell, F, Blair, GW, Jaime garcia, D, Doubal, F, Hamilton, I, Janssen, E, Kopczak, A, Ingrisch, M, Kerkhofs, D, Backes, WH, Staals, J, Duering, M, Dichgans, M & Wardlaw, JM 2023, 'Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease', Journal of Cerebral Blood Flow and Metabolism, pp. 0271678X2311734. https://doi.org/10.1177/0271678X231173444

TY - JOUR

T1 - Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease

AU - Rudilosso, Salvatore

AU - Stringer, Michael S

AU - Thrippleton, Michael

AU - Chappell, Francesca

AU - Blair, Gordon W

AU - Jaime garcia, Daniela

AU - Doubal, Fergus

AU - Hamilton, Iona

AU - Janssen, Esther

AU - Kopczak, Anna

AU - Ingrisch, Michael

AU - Kerkhofs, Danielle

AU - Backes, Walter H

AU - Staals, Julie

AU - Duering, Marco

AU - Dichgans, Martin

AU - Wardlaw, Joanna M

N1 - Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: SR receives funding from Instituto de Salud Carlos III, with a grant for health research and a mobility grant (CM18/00116; RH041992; JR21/00011). INVESTIGATE@SVDs is funded by the European Union Horizon 2020, PHC-03-15, Project No. 666881, “SVDs@target’. This study was also supported by the Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease, Ref. No. 16 CVD 05: The Row Fogo Charitable Trust; The Row Fogo Centre for Research into Ageing and the Brain, Ref. No.: AD.ROW4.35. BRO-D.FID3668413; the Stroke Association Princess Margaret Research Development Fellowship scheme (GWB); the Stroke Association Garfield Weston Foundation Senior Clinical Lectureship and NHS Research Scotland (FND); the NHS Lothian Research and Development Office (MJT); the UK Dementia Research Institute which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society and Alzheimer's Research UK (JMW, DJG); and the Edinburgh 3T MRI scanner is funded by the Wellcome Trust (104916/Z/14/Z), Dunhill Trust (R380R/1114), the Edinburgh and Lothians Health Foundation (2012/17), the Muir Maxwell Research Fund, and the University of Edinburgh. The procurement of the MRI scanner in Munich was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) grant for major research instrumentation (DFG, INST 409/193-1 FUGG). For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. Acknowledgements Publisher Copyright: © The Author(s) 2023.

PY - 2023/5/3

Y1 - 2023/5/3

U2 - 10.1177/0271678X231173444

DO - 10.1177/0271678X231173444

M3 - Article

SN - 1559-7016

SP - 0271678X2311734

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

ER -