Blood vessels as a source of progenitor cells in human embryonic and adult life

Mihaela Crisan; B. Zhengs; E. Zambidis; S. Yap; M. Tavian; B. Sun; J. P. Giacobino; L. Casteilla; J. Huard; B. Peault

Blood vessels as a source of progenitor cells in human embryonic and adult life

Mihaela Crisan, B. Zhengs, E. Zambidis, S. Yap, M. Tavian, B. Sun, J. P. Giacobino, L. Casteilla, J. Huard, B. Peault

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract / Description of output

Recent experimental results in culture and in vivo are summarized that show the existence of developmental relationships between cells that build up blood vessel walls and some previously unrelated tissues and organs. It was formerly demonstrated, in lower vertebrates as well as mammals, including humans, that discrete subsets of blood-forming endothelial cells play a key role in the emergence of the definitive hematopoietic system. We have also documented the existence in human skeletal muscle of endothelium-borne, extremely potent myogenic progenitor cells. Finally, we have characterized and purified perivascular cells-or pericytes-from human tissues and demonstrated their ability to give rise to mesodermal differentiated derivatives, principally skeletal muscle.

Original language	English
Title of host publication	STEM CELLS AND THEIR POTENTIAL FOR CLINICAL APPLICATION
Editors	NM Bilko, B Fehse, W Ostertag, C Stocking, AR Zander
Place of Publication	DORDRECHT
Publisher	Springer
Pages	137-147
Number of pages	11
ISBN (Print)	978-1-4020-6467-8
Publication status	Published - 2008
Event	NATO Advanced Research Workshop on Stem Cells and Their Potential for Clinical Application - Kiev Duration: 23 Aug 2006 → 31 Aug 2006

Conference

Conference	NATO Advanced Research Workshop on Stem Cells and Their Potential for Clinical Application
City	Kiev
Period	23/08/06 → 31/08/06

Cite this

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title = "Blood vessels as a source of progenitor cells in human embryonic and adult life",

abstract = "Recent experimental results in culture and in vivo are summarized that show the existence of developmental relationships between cells that build up blood vessel walls and some previously unrelated tissues and organs. It was formerly demonstrated, in lower vertebrates as well as mammals, including humans, that discrete subsets of blood-forming endothelial cells play a key role in the emergence of the definitive hematopoietic system. We have also documented the existence in human skeletal muscle of endothelium-borne, extremely potent myogenic progenitor cells. Finally, we have characterized and purified perivascular cells-or pericytes-from human tissues and demonstrated their ability to give rise to mesodermal differentiated derivatives, principally skeletal muscle.",

author = "Mihaela Crisan and B. Zhengs and E. Zambidis and S. Yap and M. Tavian and B. Sun and Giacobino, {J. P.} and L. Casteilla and J. Huard and B. Peault",

year = "2008",

language = "English",

isbn = "978-1-4020-6467-8",

pages = "137--147",

editor = "NM Bilko and B Fehse and W Ostertag and C Stocking and AR Zander",

booktitle = "STEM CELLS AND THEIR POTENTIAL FOR CLINICAL APPLICATION",

publisher = "Springer",

note = "NATO Advanced Research Workshop on Stem Cells and Their Potential for Clinical Application ; Conference date: 23-08-2006 Through 31-08-2006",

}

Crisan, M, Zhengs, B, Zambidis, E, Yap, S, Tavian, M, Sun, B, Giacobino, JP, Casteilla, L, Huard, J & Peault, B 2008, Blood vessels as a source of progenitor cells in human embryonic and adult life. in NM Bilko, B Fehse, W Ostertag, C Stocking & AR Zander (eds), STEM CELLS AND THEIR POTENTIAL FOR CLINICAL APPLICATION. Springer, DORDRECHT, pp. 137-147, NATO Advanced Research Workshop on Stem Cells and Their Potential for Clinical Application, Kiev, 23/08/06.

TY - CHAP

T1 - Blood vessels as a source of progenitor cells in human embryonic and adult life

AU - Crisan, Mihaela

AU - Zhengs, B.

AU - Zambidis, E.

AU - Yap, S.

AU - Tavian, M.

AU - Sun, B.

AU - Giacobino, J. P.

AU - Casteilla, L.

AU - Huard, J.

AU - Peault, B.

PY - 2008

Y1 - 2008

N2 - Recent experimental results in culture and in vivo are summarized that show the existence of developmental relationships between cells that build up blood vessel walls and some previously unrelated tissues and organs. It was formerly demonstrated, in lower vertebrates as well as mammals, including humans, that discrete subsets of blood-forming endothelial cells play a key role in the emergence of the definitive hematopoietic system. We have also documented the existence in human skeletal muscle of endothelium-borne, extremely potent myogenic progenitor cells. Finally, we have characterized and purified perivascular cells-or pericytes-from human tissues and demonstrated their ability to give rise to mesodermal differentiated derivatives, principally skeletal muscle.

AB - Recent experimental results in culture and in vivo are summarized that show the existence of developmental relationships between cells that build up blood vessel walls and some previously unrelated tissues and organs. It was formerly demonstrated, in lower vertebrates as well as mammals, including humans, that discrete subsets of blood-forming endothelial cells play a key role in the emergence of the definitive hematopoietic system. We have also documented the existence in human skeletal muscle of endothelium-borne, extremely potent myogenic progenitor cells. Finally, we have characterized and purified perivascular cells-or pericytes-from human tissues and demonstrated their ability to give rise to mesodermal differentiated derivatives, principally skeletal muscle.

M3 - Chapter

SN - 978-1-4020-6467-8

SP - 137

EP - 147

BT - STEM CELLS AND THEIR POTENTIAL FOR CLINICAL APPLICATION

A2 - Bilko, NM

A2 - Fehse, B

A2 - Ostertag, W

A2 - Stocking, C

A2 - Zander, AR

PB - Springer

CY - DORDRECHT

T2 - NATO Advanced Research Workshop on Stem Cells and Their Potential for Clinical Application

Y2 - 23 August 2006 through 31 August 2006

ER -

Blood vessels as a source of progenitor cells in human embryonic and adult life

Abstract / Description of output

Conference

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