BODIPY-Labeled Cyclobutanes by Secondary C(sp3)─H Arylations for Live-Cell Imaging

Matteo Virelli; Wei Wang; Rositha Kuniyil; Jun Wu; Giuseppe Zanoni; Antonio Fernandez Vargas; Jamie Scott; Marc Vendrell Escobar; Lutz Ackermann

doi:10.1002/chem.201903461

BODIPY-Labeled Cyclobutanes by Secondary C(sp3)─H Arylations for Live-Cell Imaging

Matteo Virelli, Wei Wang, Rositha Kuniyil, Jun Wu, Giuseppe Zanoni, Antonio Fernandez Vargas, Jamie Scott, Marc Vendrell Escobar, Lutz Ackermann

Research output: Contribution to journal › Article › peer-review

Abstract

Arylated cyclobutanes were accessed by a versatile palladium-catalyzed secondary C(sp3)–H activations exploiting chelation assistance by modular triazoles. The C−H arylation led to cyclobutane natural product derivatives in a highly regioselective fashion, setting the stage for the rapid access to novel fluorogenic BODIPY-labeled probes for live-cell imaging.

Original language	English
Journal	Chemistry - A European Journal
Early online date	21 Aug 2019
DOIs	https://doi.org/10.1002/chem.201903461
Publication status	Published - Oct 2019

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10.1002/chem.201903461

2019-CEJ-Virelli accepted manuscriptAccepted author manuscript, 1.11 MB

https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201903461

Dynamic Activatable Fluorophores
Vendrell Escobar, M. (Principal Investigator)
EU government bodies
1/06/18 → 31/05/23
Project: Research
Fellowship for Antonio Fernandez. FLUORODRUGS: Smart Theranostic Agents for the Tumour Microenvironment
Vendrell Escobar, M. (Principal Investigator)
EU government bodies
1/01/17 → 31/12/18
Project: Research

Cite this

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title = "BODIPY-Labeled Cyclobutanes by Secondary C(sp3)─H Arylations for Live-Cell Imaging",

abstract = "Arylated cyclobutanes were accessed by a versatile palladium-catalyzed secondary C(sp3)–H activations exploiting chelation assistance by modular triazoles. The C−H arylation led to cyclobutane natural product derivatives in a highly regioselective fashion, setting the stage for the rapid access to novel fluorogenic BODIPY-labeled probes for live-cell imaging. ",

author = "Matteo Virelli and Wei Wang and Rositha Kuniyil and Jun Wu and Giuseppe Zanoni and {Fernandez Vargas}, Antonio and Jamie Scott and {Vendrell Escobar}, Marc and Lutz Ackermann",

year = "2019",

month = oct,

doi = "10.1002/chem.201903461",

language = "English",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "Wiley-VCH Verlag",

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TY - JOUR

T1 - BODIPY-Labeled Cyclobutanes by Secondary C(sp3)─H Arylations for Live-Cell Imaging

AU - Virelli, Matteo

AU - Wang, Wei

AU - Kuniyil, Rositha

AU - Wu, Jun

AU - Zanoni, Giuseppe

AU - Fernandez Vargas, Antonio

AU - Scott, Jamie

AU - Vendrell Escobar, Marc

AU - Ackermann, Lutz

PY - 2019/10

Y1 - 2019/10

N2 - Arylated cyclobutanes were accessed by a versatile palladium-catalyzed secondary C(sp3)–H activations exploiting chelation assistance by modular triazoles. The C−H arylation led to cyclobutane natural product derivatives in a highly regioselective fashion, setting the stage for the rapid access to novel fluorogenic BODIPY-labeled probes for live-cell imaging.

AB - Arylated cyclobutanes were accessed by a versatile palladium-catalyzed secondary C(sp3)–H activations exploiting chelation assistance by modular triazoles. The C−H arylation led to cyclobutane natural product derivatives in a highly regioselective fashion, setting the stage for the rapid access to novel fluorogenic BODIPY-labeled probes for live-cell imaging.

U2 - 10.1002/chem.201903461

DO - 10.1002/chem.201903461

M3 - Article

SN - 0947-6539

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

ER -

BODIPY-Labeled Cyclobutanes by Secondary C(sp3)─H Arylations for Live-Cell Imaging

Abstract

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Projects

Dynamic Activatable Fluorophores

Fellowship for Antonio Fernandez. FLUORODRUGS: Smart Theranostic Agents for the Tumour Microenvironment

Cite this