Bone marrow adipose tissue

William P. Cawthorn

doi:10.1016/B978-0-12-801238-3.11207-3

Bone marrow adipose tissue

William P. Cawthorn^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract / Description of output

Bone marrow adipose tissue (BMAT) accounts for approximately 70% of total bone marrow (BM) volume and over 10% of total adipose mass in lean, healthy humans. BMAT further increases with aging and in diverse clinical conditions, including osteoporosis, obesity, and with glucocorticoid treatment. The existence of bone marrow adipocytes (BMAds) has been noted for 150 years, yet their physiological roles and pathological implications have remained poorly understood. However, increasing research interest in BMAds is beginning to elucidate these functions, including their endocrine and metabolic properties and the impact of BMAds on skeletal remodeling, hematopoiesis, tumor progression and beyond.

Original language	English
Title of host publication	Encyclopedia of Bone Biology
Publisher	Elsevier
Pages	156-177
Number of pages	22
ISBN (Electronic)	9780128140819
ISBN (Print)	9780128140826
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.11207-3
Publication status	Published - 26 Jun 2020

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title = "Bone marrow adipose tissue",

abstract = "Bone marrow adipose tissue (BMAT) accounts for approximately 70% of total bone marrow (BM) volume and over 10% of total adipose mass in lean, healthy humans. BMAT further increases with aging and in diverse clinical conditions, including osteoporosis, obesity, and with glucocorticoid treatment. The existence of bone marrow adipocytes (BMAds) has been noted for 150 years, yet their physiological roles and pathological implications have remained poorly understood. However, increasing research interest in BMAds is beginning to elucidate these functions, including their endocrine and metabolic properties and the impact of BMAds on skeletal remodeling, hematopoiesis, tumor progression and beyond.",

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N2 - Bone marrow adipose tissue (BMAT) accounts for approximately 70% of total bone marrow (BM) volume and over 10% of total adipose mass in lean, healthy humans. BMAT further increases with aging and in diverse clinical conditions, including osteoporosis, obesity, and with glucocorticoid treatment. The existence of bone marrow adipocytes (BMAds) has been noted for 150 years, yet their physiological roles and pathological implications have remained poorly understood. However, increasing research interest in BMAds is beginning to elucidate these functions, including their endocrine and metabolic properties and the impact of BMAds on skeletal remodeling, hematopoiesis, tumor progression and beyond.

AB - Bone marrow adipose tissue (BMAT) accounts for approximately 70% of total bone marrow (BM) volume and over 10% of total adipose mass in lean, healthy humans. BMAT further increases with aging and in diverse clinical conditions, including osteoporosis, obesity, and with glucocorticoid treatment. The existence of bone marrow adipocytes (BMAds) has been noted for 150 years, yet their physiological roles and pathological implications have remained poorly understood. However, increasing research interest in BMAds is beginning to elucidate these functions, including their endocrine and metabolic properties and the impact of BMAds on skeletal remodeling, hematopoiesis, tumor progression and beyond.

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U2 - 10.1016/B978-0-12-801238-3.11207-3

DO - 10.1016/B978-0-12-801238-3.11207-3

M3 - Chapter (peer-reviewed)

AN - SCOPUS:85117775307

SN - 9780128140826

SP - 156

EP - 177

BT - Encyclopedia of Bone Biology

PB - Elsevier

ER -

Bone marrow adipose tissue

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