Bone marrow adipose tissue

William P. Cawthorn*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract / Description of output

Bone marrow adipose tissue (BMAT) accounts for approximately 70% of total bone marrow (BM) volume and over 10% of total adipose mass in lean, healthy humans. BMAT further increases with aging and in diverse clinical conditions, including osteoporosis, obesity, and with glucocorticoid treatment. The existence of bone marrow adipocytes (BMAds) has been noted for 150 years, yet their physiological roles and pathological implications have remained poorly understood. However, increasing research interest in BMAds is beginning to elucidate these functions, including their endocrine and metabolic properties and the impact of BMAds on skeletal remodeling, hematopoiesis, tumor progression and beyond.
Original languageEnglish
Title of host publicationEncyclopedia of Bone Biology
Number of pages22
ISBN (Electronic)9780128140819
ISBN (Print)9780128140826
Publication statusPublished - 26 Jun 2020


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