Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

William P. Cawthorn; Erica L. Scheller; Brian S. Learman; Sebastian D. Parlee; Becky R. Simon; Hiroyuki Mori; Xiaomin Ning; Adam J. Bree; Benjamin Schell; David T. Broome; Sandra S. Soliman; Jenifer L. DelProposto; Carey N. Lumeng; Aditi Mitra; Sandeep V. Pandit; Katherine A. Gallagher; Joshua D. Miller; Venkatesh Krishnan; Susanta K. Hui; Miriam A. Bredella; Pouneh K. Fazeli; Anne Klibanski; Mark C. Horowitz; Clifford J. Rosen; Ormond A. MacDougald

doi:10.1016/j.cmet.2014.06.003

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

William P. Cawthorn^*, Erica L. Scheller, Brian S. Learman, Sebastian D. Parlee, Becky R. Simon, Hiroyuki Mori, Xiaomin Ning, Adam J. Bree, Benjamin Schell, David T. Broome, Sandra S. Soliman, Jenifer L. DelProposto, Carey N. Lumeng, Aditi Mitra, Sandeep V. Pandit, Katherine A. Gallagher, Joshua D. Miller, Venkatesh Krishnan, Susanta K. Hui, Miriam A. BredellaPouneh K. Fazeli, Anne Klibanski, Mark C. Horowitz, Clifford J. Rosen, Ormond A. MacDougald

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health. Circulating adiponectin increases in lean states such as caloric restriction (CR), but the reasons for this paradox remain unclear. Unlike white adipose tissue (WAT), bone marrow adipose tissue (MAT) increases during CR, and both MAT and serum adiponectin increase in many other clinical conditions. Thus, we investigated whether MAT contributes to circulating adiponectin. We find that adiponectin secretion is greater from MAT than WAT. Notably, specific inhibition of MAT formation in mice results in decreased circulating adiponectin during CR despite unaltered adiponectin expression in WAT. Inhibiting MAT formation also alters skeletal muscle adaptation to CR, suggesting that MAT exerts systemic effects. Finally, we reveal that both MAT and serum adiponectin increase during cancer therapy in humans. These observations identify MAT as an endocrine organ that contributes significantly to increased serum adiponectin during CR and perhaps in other adverse states.

Original language	English
Pages (from-to)	368-375
Number of pages	8
Journal	Cell Metabolism
Volume	20
Issue number	2
Early online date	3 Jul 2014
DOIs	https://doi.org/10.1016/j.cmet.2014.06.003
Publication status	Published - 5 Aug 2014

Keywords / Materials (for Non-textual outputs)

ANOREXIA-NERVOSA
METABOLISM
EXPRESSION
MICE
PROTEIN
DIET
DIFFERENTIATION
MITOCHONDRIAL
PREGNANCY
GLUCOSE

Access to Document

10.1016/j.cmet.2014.06.003

9 Invited talk
4 Participation in conference
1 Oral presentation

Adipocytes and Bone
Will Cawthorn (Invited speaker)
24 Jun 2020
Activity: Academic talk or presentation types › Invited talk
Sex & fat & blood & bones: Bone marrow fat as a novel regulator of immune function, bone biology and cardiometabolic health
Will Cawthorn (Speaker)
14 May 2020
Activity: Academic talk or presentation types › Oral presentation
Metabolic and endocrine functions of bone marrow adipocytes
Will Cawthorn (Invited speaker)
22 Aug 2019
Activity: Academic talk or presentation types › Invited talk

William Cawthorn
- Deanery of Clinical Sciences - Senior Lecturer
- Centre for Cardiovascular Science
Person: Academic: Research Active

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Cawthorn, W. P., Scheller, E. L., Learman, B. S., Parlee, S. D., Simon, B. R., Mori, H., Ning, X., Bree, A. J., Schell, B., Broome, D. T., Soliman, S. S., DelProposto, J. L., Lumeng, C. N., Mitra, A., Pandit, S. V., Gallagher, K. A., Miller, J. D., Krishnan, V., Hui, S. K., ... MacDougald, O. A. (2014). Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction. Cell Metabolism, 20(2), 368-375. https://doi.org/10.1016/j.cmet.2014.06.003

@article{0c7c9e5058ea4fb18ed7d5b8665e9996,

title = "Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction",

abstract = "The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health. Circulating adiponectin increases in lean states such as caloric restriction (CR), but the reasons for this paradox remain unclear. Unlike white adipose tissue (WAT), bone marrow adipose tissue (MAT) increases during CR, and both MAT and serum adiponectin increase in many other clinical conditions. Thus, we investigated whether MAT contributes to circulating adiponectin. We find that adiponectin secretion is greater from MAT than WAT. Notably, specific inhibition of MAT formation in mice results in decreased circulating adiponectin during CR despite unaltered adiponectin expression in WAT. Inhibiting MAT formation also alters skeletal muscle adaptation to CR, suggesting that MAT exerts systemic effects. Finally, we reveal that both MAT and serum adiponectin increase during cancer therapy in humans. These observations identify MAT as an endocrine organ that contributes significantly to increased serum adiponectin during CR and perhaps in other adverse states.",

keywords = "ANOREXIA-NERVOSA, METABOLISM, EXPRESSION, MICE, PROTEIN, DIET, DIFFERENTIATION, MITOCHONDRIAL, PREGNANCY, GLUCOSE",

author = "Cawthorn, {William P.} and Scheller, {Erica L.} and Learman, {Brian S.} and Parlee, {Sebastian D.} and Simon, {Becky R.} and Hiroyuki Mori and Xiaomin Ning and Bree, {Adam J.} and Benjamin Schell and Broome, {David T.} and Soliman, {Sandra S.} and DelProposto, {Jenifer L.} and Lumeng, {Carey N.} and Aditi Mitra and Pandit, {Sandeep V.} and Gallagher, {Katherine A.} and Miller, {Joshua D.} and Venkatesh Krishnan and Hui, {Susanta K.} and Bredella, {Miriam A.} and Fazeli, {Pouneh K.} and Anne Klibanski and Horowitz, {Mark C.} and Rosen, {Clifford J.} and MacDougald, {Ormond A.}",

year = "2014",

month = aug,

day = "5",

doi = "10.1016/j.cmet.2014.06.003",

language = "English",

volume = "20",

pages = "368--375",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "2",

}

Cawthorn, WP, Scheller, EL, Learman, BS, Parlee, SD, Simon, BR, Mori, H, Ning, X, Bree, AJ, Schell, B, Broome, DT, Soliman, SS, DelProposto, JL, Lumeng, CN, Mitra, A, Pandit, SV, Gallagher, KA, Miller, JD, Krishnan, V, Hui, SK, Bredella, MA, Fazeli, PK, Klibanski, A, Horowitz, MC, Rosen, CJ & MacDougald, OA 2014, 'Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction', Cell Metabolism, vol. 20, no. 2, pp. 368-375. https://doi.org/10.1016/j.cmet.2014.06.003

TY - JOUR

T1 - Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

AU - Cawthorn, William P.

AU - Scheller, Erica L.

AU - Learman, Brian S.

AU - Parlee, Sebastian D.

AU - Simon, Becky R.

AU - Mori, Hiroyuki

AU - Ning, Xiaomin

AU - Bree, Adam J.

AU - Schell, Benjamin

AU - Broome, David T.

AU - Soliman, Sandra S.

AU - DelProposto, Jenifer L.

AU - Lumeng, Carey N.

AU - Mitra, Aditi

AU - Pandit, Sandeep V.

AU - Gallagher, Katherine A.

AU - Miller, Joshua D.

AU - Krishnan, Venkatesh

AU - Hui, Susanta K.

AU - Bredella, Miriam A.

AU - Fazeli, Pouneh K.

AU - Klibanski, Anne

AU - Horowitz, Mark C.

AU - Rosen, Clifford J.

AU - MacDougald, Ormond A.

PY - 2014/8/5

Y1 - 2014/8/5

N2 - The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health. Circulating adiponectin increases in lean states such as caloric restriction (CR), but the reasons for this paradox remain unclear. Unlike white adipose tissue (WAT), bone marrow adipose tissue (MAT) increases during CR, and both MAT and serum adiponectin increase in many other clinical conditions. Thus, we investigated whether MAT contributes to circulating adiponectin. We find that adiponectin secretion is greater from MAT than WAT. Notably, specific inhibition of MAT formation in mice results in decreased circulating adiponectin during CR despite unaltered adiponectin expression in WAT. Inhibiting MAT formation also alters skeletal muscle adaptation to CR, suggesting that MAT exerts systemic effects. Finally, we reveal that both MAT and serum adiponectin increase during cancer therapy in humans. These observations identify MAT as an endocrine organ that contributes significantly to increased serum adiponectin during CR and perhaps in other adverse states.

AB - The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health. Circulating adiponectin increases in lean states such as caloric restriction (CR), but the reasons for this paradox remain unclear. Unlike white adipose tissue (WAT), bone marrow adipose tissue (MAT) increases during CR, and both MAT and serum adiponectin increase in many other clinical conditions. Thus, we investigated whether MAT contributes to circulating adiponectin. We find that adiponectin secretion is greater from MAT than WAT. Notably, specific inhibition of MAT formation in mice results in decreased circulating adiponectin during CR despite unaltered adiponectin expression in WAT. Inhibiting MAT formation also alters skeletal muscle adaptation to CR, suggesting that MAT exerts systemic effects. Finally, we reveal that both MAT and serum adiponectin increase during cancer therapy in humans. These observations identify MAT as an endocrine organ that contributes significantly to increased serum adiponectin during CR and perhaps in other adverse states.

KW - ANOREXIA-NERVOSA

KW - METABOLISM

KW - EXPRESSION

KW - MICE

KW - PROTEIN

KW - DIET

KW - DIFFERENTIATION

KW - MITOCHONDRIAL

KW - PREGNANCY

KW - GLUCOSE

U2 - 10.1016/j.cmet.2014.06.003

DO - 10.1016/j.cmet.2014.06.003

M3 - Article

SN - 1550-4131

VL - 20

SP - 368

EP - 375

JO - Cell Metabolism

JF - Cell Metabolism

IS - 2

ER -

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

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Keywords / Materials (for Non-textual outputs)

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Activities

Adipocytes and Bone

Sex & fat & blood & bones: Bone marrow fat as a novel regulator of immune function, bone biology and cardiometabolic health

Metabolic and endocrine functions of bone marrow adipocytes

Profiles

William Cawthorn

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