Bones hold the key to DNA virus history and epidemiology

M. Toppinen; M. F. Perdomo; J. U. Palo; Peter Simmonds; Samantha Lycett; M. Soderlund-Venermo; Antti Sajantila; K. Hedman

doi:10.1038/srep17226

Bones hold the key to DNA virus history and epidemiology

M. Toppinen, M. F. Perdomo, J. U. Palo, Peter Simmonds, Samantha Lycett, M. Soderlund-Venermo, Antti Sajantila, K. Hedman

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

DNA in human skeletal remains represents an important historical source of host genomic information and potentially of infecting viruses. However, little is known about viral persistence in bone. We searched ca. 70-year-old long bones of putative Finnish casualties from World War II for parvovirus B19 (B19V) DNA, and found a remarkable prevalence of 45%. The viral sequences were exclusively of genotypes 2 (n = 41), which disappeared from circulation in 1970´s, or genotype 3 (n = 2), which has never been reported in Northern Europe. Based on mitochondrial and Y-chromosome profiling, the two individuals carrying B19V genotype 3 were likely from the Soviet Red Army. The most recent common ancestor for all genotypes was estimated at early 1800s. This work demonstrates the forms of B19V that circulated in the first half of the 20th century and provides the first evidence of the suitability of bone for exploration of DNA viruses.

Original language	English
Article number	17226
Journal	Scientific Reports
Volume	5
Early online date	27 Nov 2015
DOIs	https://doi.org/10.1038/srep17226
Publication status	E-pub ahead of print - 27 Nov 2015

Keywords / Materials (for Non-textual outputs)

Parvovirus B19, Human
ANCIENT DNA
PHYLOGENETIC ANALYSIS

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10.1038/srep17226

Bones hold the key to DNA virus history and epidemiology
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Cite this

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title = "Bones hold the key to DNA virus history and epidemiology",

abstract = "DNA in human skeletal remains represents an important historical source of host genomic information and potentially of infecting viruses. However, little is known about viral persistence in bone. We searched ca. 70-year-old long bones of putative Finnish casualties from World War II for parvovirus B19 (B19V) DNA, and found a remarkable prevalence of 45%. The viral sequences were exclusively of genotypes 2 (n = 41), which disappeared from circulation in 1970´s, or genotype 3 (n = 2), which has never been reported in Northern Europe. Based on mitochondrial and Y-chromosome profiling, the two individuals carrying B19V genotype 3 were likely from the Soviet Red Army. The most recent common ancestor for all genotypes was estimated at early 1800s. This work demonstrates the forms of B19V that circulated in the first half of the 20th century and provides the first evidence of the suitability of bone for exploration of DNA viruses.",

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AU - Toppinen, M.

AU - Perdomo, M. F.

AU - Palo, J. U.

AU - Simmonds, Peter

AU - Lycett, Samantha

AU - Soderlund-Venermo, M.

AU - Sajantila, Antti

AU - Hedman, K.

PY - 2015/11/27

Y1 - 2015/11/27

N2 - DNA in human skeletal remains represents an important historical source of host genomic information and potentially of infecting viruses. However, little is known about viral persistence in bone. We searched ca. 70-year-old long bones of putative Finnish casualties from World War II for parvovirus B19 (B19V) DNA, and found a remarkable prevalence of 45%. The viral sequences were exclusively of genotypes 2 (n = 41), which disappeared from circulation in 1970´s, or genotype 3 (n = 2), which has never been reported in Northern Europe. Based on mitochondrial and Y-chromosome profiling, the two individuals carrying B19V genotype 3 were likely from the Soviet Red Army. The most recent common ancestor for all genotypes was estimated at early 1800s. This work demonstrates the forms of B19V that circulated in the first half of the 20th century and provides the first evidence of the suitability of bone for exploration of DNA viruses.

AB - DNA in human skeletal remains represents an important historical source of host genomic information and potentially of infecting viruses. However, little is known about viral persistence in bone. We searched ca. 70-year-old long bones of putative Finnish casualties from World War II for parvovirus B19 (B19V) DNA, and found a remarkable prevalence of 45%. The viral sequences were exclusively of genotypes 2 (n = 41), which disappeared from circulation in 1970´s, or genotype 3 (n = 2), which has never been reported in Northern Europe. Based on mitochondrial and Y-chromosome profiling, the two individuals carrying B19V genotype 3 were likely from the Soviet Red Army. The most recent common ancestor for all genotypes was estimated at early 1800s. This work demonstrates the forms of B19V that circulated in the first half of the 20th century and provides the first evidence of the suitability of bone for exploration of DNA viruses.

KW - Parvovirus B19, Human

KW - ANCIENT DNA

KW - PHYLOGENETIC ANALYSIS

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SN - 2045-2322

VL - 5

JO - Scientific Reports

JF - Scientific Reports

M1 - 17226

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Bones hold the key to DNA virus history and epidemiology

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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