Bovine gammadelta T Cells Are a Major Regulatory T Cell Subset

Efrain Guzman*, Jayne Hope, Geraldine Taylor, Adrian L Smith, Carolina Cubillos-Zapata, Bryan Charleston

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In humans and mice, γδ T cells represent <5% of the total circulating lymphocytes. In contrast, the γδ T cell compartment in ruminants accounts for 15-60% of the total circulating mononuclear lymphocytes. Despite the existence of CD4(+)CD25(high) Foxp3(+) T cells in the bovine system, these are neither anergic nor suppressive. We present evidence showing that bovine γδ T cells are the major regulatory T cell subset in peripheral blood. These γδ T cells spontaneously secrete IL-10 and proliferate in response to IL-10, TGF-β, and contact with APCs. IL-10-expressing γδ T cells inhibit Ag-specific and nonspecific proliferation of CD4(+) and CD8(+) T cells in vitro. APC subsets expressing IL-10 and TFG-β regulate proliferation of γδ T cells producing IL-10. We propose that γδ T cells are a major regulatory T cell population in the bovine system.

Original languageEnglish
Pages (from-to)208-222
Number of pages15
JournalJournal of Immunology
Volume193
Issue number1
Early online date20 Jun 2014
DOIs
Publication statusPublished - 20 Jun 2014

Keywords

  • MOUTH-DISEASE VIRUS
  • LYMPH DENDRITIC CELLS
  • MONOCLONAL-ANTIBODIES
  • PERIPHERAL-BLOOD
  • AFFERENT LYMPH
  • PROLIFERATIVE RESPONSES
  • RECEPTOR REPERTOIRE
  • WORKSHOP FINDINGS
  • INFECTED CATTLE
  • DOWN-REGULATION

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