Brønsted Acid‐Catalyzed General Petasis Allylation and Isoprenylation of Unactivated Ketones

Yi-yong Huang, Yang Zhou, Zhen-ni Zhao, Yu-long Zhang, Jun Liu, Quan Yuan, Uwe Schneider

Research output: Contribution to journalArticlepeer-review

Abstract

Brønsted acid‐catalyzed general Petasis allylation and isoprenylation of unactivated ketones have been developed using o ‐hydroxyaniline and the corresponding pinacolyl boronic esters. This robust methodology has provided access to a broad variety of quaternary homoallylic amines and dienylamines in high yields, proved applicable to a gram‐scale synthesis, and allowed the formation of a potentially bioactive quaternary homoallylic aminodiol.
Original languageEnglish
JournalChemistry - A European Journal
Early online date20 May 2020
DOIs
Publication statusE-pub ahead of print - 20 May 2020

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