Bradykinin B1 receptor-mediated vasodilation is impaired in myometrial arteries from women with pre-eclampsia

Amie J Moyes; Gillian A Gray; Fiona C Denison

doi:10.3109/10641955.2013.846368

Bradykinin B1 receptor-mediated vasodilation is impaired in myometrial arteries from women with pre-eclampsia

Amie J Moyes, Gillian A Gray, Fiona C Denison

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

OBJECTIVE: To investigate the vascular functional activity, localisation and expression of B1 and B2 kinin receptors in normal pregnancy and pre-eclampsia.

METHODS: Kinin receptor-mediated relaxation of myometrial arteries was assessed using wire myography. Immunohistochemical staining and gene expression of kinin receptors in the myometrium was determined.

RESULTS: B2 receptor-mediated relaxation was reduced in pre-eclampsia. B1 receptor-mediated relaxation was observed in a proportion of healthy women and was impaired in pre-eclampsia. Receptor expression and localisation was unaltered in pre-eclampsia.

CONCLUSION: Here, we demonstrate a novel B1 receptor-mediated vasodilatation in healthy myometrial vessels that is absent in pre-eclampsia.

Original language	English
Pages (from-to)	177-190
Number of pages	14
Journal	Hypertension in Pregnancy
Volume	33
Issue number	2
DOIs	https://doi.org/10.3109/10641955.2013.846368
Publication status	Published - May 2014

Keywords / Materials (for Non-textual outputs)

Endothelium
Kinin
Myometrium
Pregnancy
Pre-eclampsia
ENDOTHELIUM-DEPENDENT RELAXATION
PREGNANCY-INDUCED HYPERTENSION
KALLIKREIN-KININ SYSTEM
NITRIC-OXIDE
RESISTANCE ARTERIES
ANGIOTENSIN-II
MECHANISMS
RESPONSES
EXPRESSION
PROSTACYCLIN

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10.3109/10641955.2013.846368

The role of bradykinin in mediating endothelial and fibrinolytic dysfunction in pre-eclampsia
Riley, S., Calder, A., Cruden, N., Denison, F., Megson, I., Newby, D. & Weller, R.
UK-based charities
3/08/05 → 31/07/08
Project: Research

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@article{59d52543d04849dc991862a91a110843,

title = "Bradykinin B1 receptor-mediated vasodilation is impaired in myometrial arteries from women with pre-eclampsia",

abstract = "OBJECTIVE: To investigate the vascular functional activity, localisation and expression of B1 and B2 kinin receptors in normal pregnancy and pre-eclampsia.METHODS: Kinin receptor-mediated relaxation of myometrial arteries was assessed using wire myography. Immunohistochemical staining and gene expression of kinin receptors in the myometrium was determined.RESULTS: B2 receptor-mediated relaxation was reduced in pre-eclampsia. B1 receptor-mediated relaxation was observed in a proportion of healthy women and was impaired in pre-eclampsia. Receptor expression and localisation was unaltered in pre-eclampsia.CONCLUSION: Here, we demonstrate a novel B1 receptor-mediated vasodilatation in healthy myometrial vessels that is absent in pre-eclampsia.",

keywords = "Endothelium, Kinin, Myometrium, Pregnancy, Pre-eclampsia, ENDOTHELIUM-DEPENDENT RELAXATION, PREGNANCY-INDUCED HYPERTENSION, KALLIKREIN-KININ SYSTEM, NITRIC-OXIDE, RESISTANCE ARTERIES, ANGIOTENSIN-II, MECHANISMS, RESPONSES, EXPRESSION, PROSTACYCLIN",

author = "Moyes, {Amie J} and Gray, {Gillian A} and Denison, {Fiona C}",

year = "2014",

month = may,

doi = "10.3109/10641955.2013.846368",

language = "English",

volume = "33",

pages = "177--190",

journal = "Hypertension in Pregnancy",

issn = "1064-1955",

publisher = "Informa Healthcare",

number = "2",

}

TY - JOUR

T1 - Bradykinin B1 receptor-mediated vasodilation is impaired in myometrial arteries from women with pre-eclampsia

AU - Moyes, Amie J

AU - Gray, Gillian A

AU - Denison, Fiona C

PY - 2014/5

Y1 - 2014/5

N2 - OBJECTIVE: To investigate the vascular functional activity, localisation and expression of B1 and B2 kinin receptors in normal pregnancy and pre-eclampsia.METHODS: Kinin receptor-mediated relaxation of myometrial arteries was assessed using wire myography. Immunohistochemical staining and gene expression of kinin receptors in the myometrium was determined.RESULTS: B2 receptor-mediated relaxation was reduced in pre-eclampsia. B1 receptor-mediated relaxation was observed in a proportion of healthy women and was impaired in pre-eclampsia. Receptor expression and localisation was unaltered in pre-eclampsia.CONCLUSION: Here, we demonstrate a novel B1 receptor-mediated vasodilatation in healthy myometrial vessels that is absent in pre-eclampsia.

AB - OBJECTIVE: To investigate the vascular functional activity, localisation and expression of B1 and B2 kinin receptors in normal pregnancy and pre-eclampsia.METHODS: Kinin receptor-mediated relaxation of myometrial arteries was assessed using wire myography. Immunohistochemical staining and gene expression of kinin receptors in the myometrium was determined.RESULTS: B2 receptor-mediated relaxation was reduced in pre-eclampsia. B1 receptor-mediated relaxation was observed in a proportion of healthy women and was impaired in pre-eclampsia. Receptor expression and localisation was unaltered in pre-eclampsia.CONCLUSION: Here, we demonstrate a novel B1 receptor-mediated vasodilatation in healthy myometrial vessels that is absent in pre-eclampsia.

KW - Endothelium

KW - Kinin

KW - Myometrium

KW - Pregnancy

KW - Pre-eclampsia

KW - ENDOTHELIUM-DEPENDENT RELAXATION

KW - PREGNANCY-INDUCED HYPERTENSION

KW - KALLIKREIN-KININ SYSTEM

KW - NITRIC-OXIDE

KW - RESISTANCE ARTERIES

KW - ANGIOTENSIN-II

KW - MECHANISMS

KW - RESPONSES

KW - EXPRESSION

KW - PROSTACYCLIN

U2 - 10.3109/10641955.2013.846368

DO - 10.3109/10641955.2013.846368

M3 - Article

C2 - 24304135

SN - 1064-1955

VL - 33

SP - 177

EP - 190

JO - Hypertension in Pregnancy

JF - Hypertension in Pregnancy

IS - 2

ER -

Bradykinin B1 receptor-mediated vasodilation is impaired in myometrial arteries from women with pre-eclampsia

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Keywords / Materials (for Non-textual outputs)

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The role of bradykinin in mediating endothelial and fibrinolytic dysfunction in pre-eclampsia

Cite this