Brain-derived neurotrophic factor serum levels in cocaine-dependent patients during early abstinence.

Margarida Corominas-Roso, Carlos Roncero, Francisco Jose Eiroa-Orosa, Begoña Gonzalvo, Lara Grau-Lopez, Marta Ribases, Laia Rodriguez-Cintas, Cristina Sánchez-Mora, Josep-Antoni Ramos-Quiroga, Miguel Casas

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Abstract

Preclinical studies indicate that brain-derived neurotrophic factor (BDNF) is involved in neuroplastic changes underlying enduring cocaine-seeking following withdrawal. However, little is known about temporal changes in serum BDNF levels or the involvement of BDNF in craving and abstinence in early-abstinent cocaine-dependent patients. Twenty-three cocaine-dependent individuals (aged 33.65±6.85 years) completed a two-week detoxification program at an inpatient facility. Two serum samples were collected for each patient at baseline and at the end of the protocol. Serum samples were also collected for 46 healthy controls (aged 35.52±9.37 years). Demographic, consumption and clinical data were recorded for all patients. Significantly lower serum BDNF levels (p
Original languageUndefined/Unknown
JournalEuropean Neuropsychopharmacology
DOIs
Publication statusPublished - 1 Sep 2012

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