Brain-derived neurotrophic factor serum levels in cocaine-dependent patients during early abstinence.

Margarida Corominas-Roso; Carlos Roncero; Francisco Jose Eiroa-Orosa; Begoña Gonzalvo; Lara Grau-Lopez; Marta Ribases; Laia Rodriguez-Cintas; Cristina Sánchez-Mora; Josep-Antoni Ramos-Quiroga; Miguel Casas

doi:10.1016/j.euroneuro.2012.08.016

Brain-derived neurotrophic factor serum levels in cocaine-dependent patients during early abstinence.

Margarida Corominas-Roso, Carlos Roncero, Francisco Jose Eiroa-Orosa, Begoña Gonzalvo, Lara Grau-Lopez, Marta Ribases, Laia Rodriguez-Cintas, Cristina Sánchez-Mora, Josep-Antoni Ramos-Quiroga, Miguel Casas

School of Health in Social Science

Research output: Contribution to journal › Article › peer-review

Abstract

Preclinical studies indicate that brain-derived neurotrophic factor (BDNF) is involved in neuroplastic changes underlying enduring cocaine-seeking following withdrawal. However, little is known about temporal changes in serum BDNF levels or the involvement of BDNF in craving and abstinence in early-abstinent cocaine-dependent patients. Twenty-three cocaine-dependent individuals (aged 33.65Â±6.85 years) completed a two-week detoxification program at an inpatient facility. Two serum samples were collected for each patient at baseline and at the end of the protocol. Serum samples were also collected for 46 healthy controls (aged 35.52Â±9.37 years). Demographic, consumption and clinical data were recorded for all patients. Significantly lower serum BDNF levels (p

Original language	Undefined/Unknown
Journal	European Neuropsychopharmacology
DOIs	https://doi.org/10.1016/j.euroneuro.2012.08.016
Publication status	Published - 1 Sept 2012

Access to Document

10.1016/j.euroneuro.2012.08.016

http://dx.doi.org/10.1016/j.euroneuro.2012.08.016

Cite this

@article{478af108dd504b0996bd3684b1242862,

title = "Brain-derived neurotrophic factor serum levels in cocaine-dependent patients during early abstinence.",

abstract = "Preclinical studies indicate that brain-derived neurotrophic factor (BDNF) is involved in neuroplastic changes underlying enduring cocaine-seeking following withdrawal. However, little is known about temporal changes in serum BDNF levels or the involvement of BDNF in craving and abstinence in early-abstinent cocaine-dependent patients. Twenty-three cocaine-dependent individuals (aged 33.65{\^A}±6.85 years) completed a two-week detoxification program at an inpatient facility. Two serum samples were collected for each patient at baseline and at the end of the protocol. Serum samples were also collected for 46 healthy controls (aged 35.52{\^A}±9.37 years). Demographic, consumption and clinical data were recorded for all patients. Significantly lower serum BDNF levels (p",

author = "Margarida Corominas-Roso and Carlos Roncero and Eiroa-Orosa, {Francisco Jose} and Bego{\~n}a Gonzalvo and Lara Grau-Lopez and Marta Ribases and Laia Rodriguez-Cintas and Cristina S{\'a}nchez-Mora and Josep-Antoni Ramos-Quiroga and Miguel Casas",

year = "2012",

month = sep,

day = "1",

doi = "10.1016/j.euroneuro.2012.08.016",

language = "Undefined/Unknown",

journal = "European Neuropsychopharmacology",

issn = "0924-977X",

publisher = "Elsevier",

}

TY - JOUR

T1 - Brain-derived neurotrophic factor serum levels in cocaine-dependent patients during early abstinence.

AU - Corominas-Roso, Margarida

AU - Roncero, Carlos

AU - Eiroa-Orosa, Francisco Jose

AU - Gonzalvo, Begoña

AU - Grau-Lopez, Lara

AU - Ribases, Marta

AU - Rodriguez-Cintas, Laia

AU - Sánchez-Mora, Cristina

AU - Ramos-Quiroga, Josep-Antoni

AU - Casas, Miguel

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Preclinical studies indicate that brain-derived neurotrophic factor (BDNF) is involved in neuroplastic changes underlying enduring cocaine-seeking following withdrawal. However, little is known about temporal changes in serum BDNF levels or the involvement of BDNF in craving and abstinence in early-abstinent cocaine-dependent patients. Twenty-three cocaine-dependent individuals (aged 33.65Â±6.85 years) completed a two-week detoxification program at an inpatient facility. Two serum samples were collected for each patient at baseline and at the end of the protocol. Serum samples were also collected for 46 healthy controls (aged 35.52Â±9.37 years). Demographic, consumption and clinical data were recorded for all patients. Significantly lower serum BDNF levels (p

AB - Preclinical studies indicate that brain-derived neurotrophic factor (BDNF) is involved in neuroplastic changes underlying enduring cocaine-seeking following withdrawal. However, little is known about temporal changes in serum BDNF levels or the involvement of BDNF in craving and abstinence in early-abstinent cocaine-dependent patients. Twenty-three cocaine-dependent individuals (aged 33.65Â±6.85 years) completed a two-week detoxification program at an inpatient facility. Two serum samples were collected for each patient at baseline and at the end of the protocol. Serum samples were also collected for 46 healthy controls (aged 35.52Â±9.37 years). Demographic, consumption and clinical data were recorded for all patients. Significantly lower serum BDNF levels (p

U2 - 10.1016/j.euroneuro.2012.08.016

DO - 10.1016/j.euroneuro.2012.08.016

M3 - Article

SN - 0924-977X

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

ER -