Brain-derived proteins in the CSF: do they correlate with brain pathology in CJD?

Constanze Boesenberg-Grosse, Walter J Schulz-Schaeffer, Monika Bodemer, Barbara Ciesielczyk, Bettina Meissner, Anna Krasnianski, Mario Bartl, Uta Heinemann, Daniela Varges, Sabina Eigenbrod, Hans A Kretzschmar, Alison Green, Inga Zerr

Research output: Contribution to journalArticlepeer-review

Abstract

Brain derived proteins such as 14-3-3, neuron-specific enolase (NSE), S 100b, tau, phosphorylated tau and Abeta1-42 were found to be altered in the cerebrospinal fluid (CSF) in Creutzfeldt-Jakob disease (CJD) patients. The pathogenic mechanisms leading to these abnormalities are not known, but a relation to rapid neuronal damage is assumed. No systematic analysis on brain-derived proteins in the CSF and neuropathological lesion profiles has been performed.
Original languageEnglish
Pages (from-to)35
JournalBmc neurology
Volume6
DOIs
Publication statusPublished - 2006

Keywords

  • 14-3-3 Proteins
  • Adult
  • Aged
  • Aged, 80 and over
  • Amyloid beta-Peptides
  • Brain
  • Creutzfeldt-Jakob Syndrome
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nerve Tissue Proteins
  • Phosphopyruvate Hydratase
  • Prions
  • S100 Proteins
  • tau Proteins

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