Abstract

Elevated glucocorticoid (GC) levels are hypothesized to be deleterious to some brain regions, including white matter (WM). Older age is accompanied by increased between-participant variation in GC levels, yet relationships between WM integrity and cortisol levels in older humans are underexplored. Moreover, it is unclear whether GC-WM associations might be general or pathway specific. We analyzed relationships between salivary cortisol (diurnal and reactive) and general measures of brain WM hyperintensity (WMH) volume, fractional anisotropy (gFA), and mean diffusivity (gMD) in 90 males, aged 73 years. Significant associations were predominantly found between cortisol measures and WMHs and gMD but not gFA. Higher cortisol at the start of a mild cognitive stressor was associated with higher WMH and gMD. Higher cortisol at the end was associated with greater WMHs. A constant or increasing cortisol level during cognitive testing was associated with lower gMD. Tract-specific bases of these associations implicated anterior thalamic radiation, uncinate, and arcuate and inferior longitudinal fasciculi. The cognitive sequelae of these relationships, above other covariates, are a priority for future study.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalNeurobiology of Aging
Volume36
Issue number1
Early online date28 Jun 2014
DOIs
Publication statusPublished - 2015

Keywords

  • Cortisol
  • Glucocorticoid
  • White matter
  • Aging
  • Brain structure
  • Tractography
  • HIPPOCAMPAL DENTATE GYRUS
  • FRACTIONAL ANISOTROPY
  • ALZHEIMERS-DISEASE
  • SALIVARY CORTISOL
  • ELDERLY-PEOPLE
  • STRESS
  • TRACTOGRAPHY
  • DEPRESSION
  • HEALTH
  • AXIS

Fingerprint Dive into the research topics of 'Brain white matter integrity and cortisol in older men: the Lothian Birth Cohort 1936'. Together they form a unique fingerprint.

Cite this