BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer

Judith E Carser; Jennifer E Quinn; Caroline O Michie; Eamonn J O'Brien; W Glenn McCluggage; Perry Maxwell; Elisabeth Lamers; Tong F Lioe; Alistair R W Williams; Richard D Kennedy; Charles Gourley; D Paul Harkin

doi:10.1016/j.ygyno.2011.08.017

BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer

Judith E Carser, Jennifer E Quinn, Caroline O Michie, Eamonn J O'Brien, W Glenn McCluggage, Perry Maxwell, Elisabeth Lamers, Tong F Lioe, Alistair R W Williams, Richard D Kennedy, Charles Gourley, D Paul Harkin

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the relationship between BRCA1 protein expression by immunohistochemistry (IHC) and clinical outcome following platinum and platinum/taxane chemotherapy in sporadic epithelial ovarian cancer (EOC).

Original language	English
Pages (from-to)	492-8
Number of pages	7
Journal	Gynecologic Oncology
Volume	123
Issue number	3
DOIs	https://doi.org/10.1016/j.ygyno.2011.08.017
Publication status	Published - 2011

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10.1016/j.ygyno.2011.08.017

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Carser, J. E., Quinn, J. E., Michie, C. O., O'Brien, E. J., McCluggage, W. G., Maxwell, P., Lamers, E., Lioe, T. F., Williams, A. R. W., Kennedy, R. D., Gourley, C., & Harkin, D. P. (2011). BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer. Gynecologic Oncology, 123(3), 492-8. https://doi.org/10.1016/j.ygyno.2011.08.017

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title = "BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer",

abstract = "We investigated the relationship between BRCA1 protein expression by immunohistochemistry (IHC) and clinical outcome following platinum and platinum/taxane chemotherapy in sporadic epithelial ovarian cancer (EOC).",

author = "Carser, {Judith E} and Quinn, {Jennifer E} and Michie, {Caroline O} and O'Brien, {Eamonn J} and McCluggage, {W Glenn} and Perry Maxwell and Elisabeth Lamers and Lioe, {Tong F} and Williams, {Alistair R W} and Kennedy, {Richard D} and Charles Gourley and Harkin, {D Paul}",

year = "2011",

doi = "10.1016/j.ygyno.2011.08.017",

language = "English",

volume = "123",

pages = "492--8",

journal = "Gynecologic Oncology",

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T1 - BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer

AU - Carser, Judith E

AU - Quinn, Jennifer E

AU - Michie, Caroline O

AU - O'Brien, Eamonn J

AU - McCluggage, W Glenn

AU - Maxwell, Perry

AU - Lamers, Elisabeth

AU - Lioe, Tong F

AU - Williams, Alistair R W

AU - Kennedy, Richard D

AU - Gourley, Charles

AU - Harkin, D Paul

PY - 2011

Y1 - 2011

N2 - We investigated the relationship between BRCA1 protein expression by immunohistochemistry (IHC) and clinical outcome following platinum and platinum/taxane chemotherapy in sporadic epithelial ovarian cancer (EOC).

AB - We investigated the relationship between BRCA1 protein expression by immunohistochemistry (IHC) and clinical outcome following platinum and platinum/taxane chemotherapy in sporadic epithelial ovarian cancer (EOC).

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U2 - 10.1016/j.ygyno.2011.08.017

DO - 10.1016/j.ygyno.2011.08.017

M3 - Article

C2 - 21920589

VL - 123

SP - 492

EP - 498

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 3

ER -

BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer

Abstract

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