Breeding in an Era of Genome Editing

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

Genome editing is, by definition, the manipulation of the genetic material of an animal by deleting, replacing or inserting a DNA sequence. There are three types of ‘genome editors’, ZFNs, TALENs and CRISPR-Cas, which are molecular tools or ‘nucleases’ that each have a similar ability to introduce double strand DNA breaks in an animal’s genome at a target site. The double strand DNA breaks stimulate endogenous cellular DNA repair which allows DNA sequences to be precisely modified or introduced into the genome (1). This powerful technology allows animal breeders to specifically and efficiently alter an animals DNA to introduce beneficial genetic variation (2). As such genome editing technologies offer exciting opportunities for breeding fitter, healthier, more productive and sustainable farmed animals
Original languageEnglish
Title of host publicationEncyclopedia of Sustainability Science and Technology
PublisherSpringer Nature
ISBN (Electronic)978-1-4939-2493-6
DOIs
Publication statusE-pub ahead of print - 14 Apr 2022

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