Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

J Nithianantharajah; A G McKechanie; T J Stewart; M Johnstone; D H Blackwood; D St Clair; S G N Grant; T J Bussey; L M Saksida

doi:10.1038/srep14613

Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

J Nithianantharajah, A G McKechanie, T J Stewart, M Johnstone, D H Blackwood, D St Clair, S G N Grant, T J Bussey, L M Saksida

Research output: Contribution to journal › Article › peer-review

Abstract

Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.

Original language	English
Pages (from-to)	14613
Journal	Scientific Reports
Volume	5
DOIs	https://doi.org/10.1038/srep14613
Publication status	Published - 1 Oct 2015

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10.1038/srep14613

Bridging the Translational Divide
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Nithianantharajah, J., McKechanie, A. G., Stewart, T. J., Johnstone, M., Blackwood, D. H., St Clair, D., Grant, S. G. N., Bussey, T. J., & Saksida, L. M. (2015). Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene. Scientific Reports, 5, 14613. https://doi.org/10.1038/srep14613

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AU - St Clair, D

AU - Grant, S G N

AU - Bussey, T J

AU - Saksida, L M

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Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

Abstract

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