Brr2p RNA helicase with a split personality: insights into structure and function

Daniela Hahn, Jean D. Beggs

Research output: Contribution to journalArticlepeer-review

Abstract

RNA helicases are involved in many cellular processes. Pre-mRNA splicing requires eight different DExD/H-box RNA helicases, which facilitate spliceosome assembly and remodelling of the intricate network of RNA rearrangement; that are central to the splicing process. Brr2p, one of the spliceosomal RNA helicases, stands out through its unusual domain architecture. in the present review we highlight the advances made by recent structural and biochemical studies that have important implications for the mechanism and regulation of Brr2p activity. We also discuss the involvement of human Brr2 in retinitis pigmentosa, a degenerative eye disease, and how its functions in splicing might connect to the molecular pathology of the disease.

Original languageEnglish
Pages (from-to)1105-1109
Number of pages5
JournalBiochemical Society Transactions
Volume38
DOIs
Publication statusPublished - Aug 2010

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