Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis

Vincent Vanoosthuyse; Kevin G Hardwick

doi:10.1016/j.tcb.2005.03.003

Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis

Vincent Vanoosthuyse, Kevin G Hardwick

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

To ensure the accuracy of chromosome segregation in mitosis, the spindle checkpoint blocks the activity of the anaphase-promoting complex APC/C until all chromosomes are properly bi-orientated on the metaphase spindle. How the checkpoint machinery actually inhibits the APC/C is still unclear. A new paper by Tang and coworkers helps further our understanding of this complex and fundamental process.

Original language	English
Pages (from-to)	231-3
Number of pages	3
Journal	Trends In Cell Biology
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/j.tcb.2005.03.003
Publication status	Published - 2005

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title = "Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis",

abstract = "To ensure the accuracy of chromosome segregation in mitosis, the spindle checkpoint blocks the activity of the anaphase-promoting complex APC/C until all chromosomes are properly bi-orientated on the metaphase spindle. How the checkpoint machinery actually inhibits the APC/C is still unclear. A new paper by Tang and coworkers helps further our understanding of this complex and fundamental process.",

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AU - Vanoosthuyse, Vincent

AU - Hardwick, Kevin G

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AB - To ensure the accuracy of chromosome segregation in mitosis, the spindle checkpoint blocks the activity of the anaphase-promoting complex APC/C until all chromosomes are properly bi-orientated on the metaphase spindle. How the checkpoint machinery actually inhibits the APC/C is still unclear. A new paper by Tang and coworkers helps further our understanding of this complex and fundamental process.

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DO - 10.1016/j.tcb.2005.03.003

M3 - Article

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JO - Trends In Cell Biology

JF - Trends In Cell Biology

SN - 0962-8924

IS - 5

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Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis

Abstract

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