Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis

Vincent Vanoosthuyse, Kevin G Hardwick

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

To ensure the accuracy of chromosome segregation in mitosis, the spindle checkpoint blocks the activity of the anaphase-promoting complex APC/C until all chromosomes are properly bi-orientated on the metaphase spindle. How the checkpoint machinery actually inhibits the APC/C is still unclear. A new paper by Tang and coworkers helps further our understanding of this complex and fundamental process.
Original languageEnglish
Pages (from-to)231-3
Number of pages3
JournalTrends In Cell Biology
Issue number5
Publication statusPublished - 2005


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