TY - JOUR
T1 - Building consensus in neuromesodermal research
T2 - Current advances and future biomedical perspectives
AU - Binagui-Casas, Anahí
AU - Dias, André
AU - Guillot, Charlène
AU - Metzis, Vicki
AU - Saunders, Dillan
N1 - Funding Information:
The authors? research is supported by the Medical Research Council (MR/S008799/1 to A.B.C), the Funda??o para a Ci?ncia e Tecnologia (PD/BD/128,426/2017 to A.D.), the National Institute of Health (RO1HD097068-02 to C.G), EMBO (ALTF 406?2015 to C.G.) and iSITE CAP2025 new team Starting grant to C.G, a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (218536/Z/19/Z to V.M), and the Wellcome Trust (220022/Z/19/Z to D.S).
Funding Information:
The authors’ research is supported by the Medical Research Council (MR/S008799/1 to A.B.C), the Fundação para a Ciência e Tecnologia (PD/BD/128,426/2017 to A.D.), the National Institute of Health (RO1HD097068-02 to C.G), EMBO (ALTF 406–2015 to C.G.) and iSITE CAP2025 new team Starting grant to C.G, a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (218536/Z/19/Z to V.M), and the Wellcome Trust (220022/Z/19/Z to D.S).
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/10/28
Y1 - 2021/10/28
N2 - The development of the vertebrate body axis relies on the activity of different populations of axial progenitors, including neuromesodermal progenitors. Currently, the term ‘Neuromesodermal progenitors’ is associated with various definitions. Here, we use distinct terminologies to highlight advances in our understanding of this cell type at both the single-cell and population levels. We discuss how these recent insights prompt new opportunities to address a range of biomedical questions spanning cancer metastasis, congenital disorders, cellular metabolism, regenerative medicine, and evolution. Finally, we outline some of the major unanswered questions and propose future directions at the forefront of neuromesodermal research.
AB - The development of the vertebrate body axis relies on the activity of different populations of axial progenitors, including neuromesodermal progenitors. Currently, the term ‘Neuromesodermal progenitors’ is associated with various definitions. Here, we use distinct terminologies to highlight advances in our understanding of this cell type at both the single-cell and population levels. We discuss how these recent insights prompt new opportunities to address a range of biomedical questions spanning cancer metastasis, congenital disorders, cellular metabolism, regenerative medicine, and evolution. Finally, we outline some of the major unanswered questions and propose future directions at the forefront of neuromesodermal research.
U2 - 10.1016/j.ceb.2021.08.003
DO - 10.1016/j.ceb.2021.08.003
M3 - Review article
AN - SCOPUS:85117895311
SN - 0955-0674
VL - 73
SP - 133
EP - 140
JO - Current opinion in cell biology
JF - Current opinion in cell biology
ER -