C-MYC translocation in t(14;18) positive follicular lymphoma at presentation: An adverse prognostic indicator?

Lesley Christie, Neil Kernohan, David Levison, Mark Sales, Joan Cunningham, Karen Gillespie, Paul Batstone, David Meiklejohn, John Goodlad

Research output: Contribution to journalArticlepeer-review

Abstract

Follicular lymphoma (FL) is a common subtype of low grade B-cell non-Hodgkin lymphoma (NHL). Although this form of lymphoma often pursues an indolent course, in some cases it may behave in a more aggressive manner. Clinical and histological parameters have been shown to correlate with an adverse prognosis but a number of cytogenetic abnormalities may also be associated with aggressive disease. Although, the t(14;18) in itself does not affect outcome in cases of FL, secondary abnormalities that occur in a complex polyploid karyotype may identify cases with a poor prognosis. It is unusual to find both t(14;18) and C-MYC translocation in the same tumour; those cases in which it has been described include examples of high-grade B-cell NHL (either de novo or transformed FL) or B-cell acute lymphoblastic lymphoma. In this report, three cases of FL are described in which both t(14;18) and a C-MYC translocation were identified at presentation. We also summarize four further cases from the literature. This is a small series but one which raises the possibility that the presence of a C-MYC translocations at presentation may identify a particularly aggressive subtype of FL. Further studies are required to investigate the true incidence of this aberration, the impact on C-MYC regulation, clinical course and response to treatment.

Original languageEnglish
Pages (from-to)470-6
Number of pages7
JournalLeukemia & Lymphoma
Volume49
Issue number3
DOIs
Publication statusPublished - Mar 2008

Keywords

  • Aged
  • Chromosomes, Human, Pair 14
  • Chromosomes, Human, Pair 18
  • Chromosomes, Human, Pair 8
  • Cytogenetic Analysis
  • Female
  • Humans
  • Lymphoma, Follicular
  • Male
  • Prognosis
  • Proto-Oncogene Proteins c-myc
  • Translocation, Genetic
  • Treatment Outcome

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